CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES

Title:

CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/058923

Kind Code:

A1

Abstract:

Quinolone derivatives represented by general formula (I), salts thereof, and hydrates thereof of both, having potent antimicrobial activities against various bacteria including resistant strains and being highly safe: wherein R?1¿ represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R?2¿ represents a halogenomethoxyl or alkoxyl group; R?3¿ represents an alkyl, alkenyl, halogenoalkyl, cyclic alkyl, heteroaryl, alkoxyl, or alkylamino group; R?4¿ represents a hydrogen atom or a phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl group. The above substituents may be further substituted.

Inventors:

TAKEMURA MAKOTO (JP)
TAKAHASHI HISASHI (JP)
OHKI HITOSHI (JP)
KIMURA KENICHI (JP)
MIYAUCHI RIE (JP)
TAKEDA TOSHIYUKI (JP)

Application Number:

PCT/JP1998/002787

Publication Date:

December 30, 1998

Filing Date:

June 23, 1998

Export Citation:

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Assignee:

DAIICHI SEIYAKU CO (JP)
TAKEMURA MAKOTO (JP)
TAKAHASHI HISASHI (JP)
OHKI HITOSHI (JP)
KIMURA KENICHI (JP)
MIYAUCHI RIE (JP)
TAKEDA TOSHIYUKI (JP)

International Classes:

C07D401/04; (IPC1-7): C07D401/04; A61K31/47; C07D207/14

Foreign References:

JPH03188074A	1991-08-16
JPS63152318A	1988-06-24
JPS6351370A	1988-03-04
JPS6219583A	1987-01-28
JPS6345261A	1988-02-26
JPH09136886A	1997-05-27
JPH0967368A	1997-03-11
JPH08277284A	1996-10-22

Other References: