Title:
CLASS OF CHIRAL AROMATIC HETEROAMINE DERIVATIVE, SYNTHESIS METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/107332
Kind Code:
A1
Abstract:
The invention belongs to the technical field of compound synthesis, and specifically discloses a class of chiral aromatic heteroamine derivative and a synthesis method and application thereof. The chiral aromatic heteroamine derivative has a structure represented by formula (I), wherein R1 and R2 are independently selected from hydrogen or halogen; R3 is an alkoxyl, phenyl, methoxyl, alkynyl, cyano or dihalogen-substituted phenyl ring, a 5- or 6-membered heterocyclic, methoxyl, alkynyl, cyano, mono- or dihalogen-substituted 5- or 6-membered heterocyclic ring, or a fused heterocyclic ring; X is oxygen or nitrogen; and Y is carbonyl or sulfonyl. The chiral aromatic heteroamine derivative synthesized by the invention has a function of inhibiting assembly of a Hepatitis B virus core protein, and thus can fundamentally inhibit replication of the Hepatitis B virus, and has wide application prospects in the treatment of Hepatitis B virus-caused diseases.
Inventors:
ZHANG HUI (CN)
BO CHUAN (CN)
PAN TING (CN)
WU LIYANG (CN)
BO CHUAN (CN)
PAN TING (CN)
WU LIYANG (CN)
Application Number:
PCT/CN2016/109522
Publication Date:
June 21, 2018
Filing Date:
December 12, 2016
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
C07D277/46; A61K31/426; A61P31/12
Foreign References:
| US20120122939A1 | 2012-05-17 | |||
| CN101835765A | 2010-09-15 |
Attorney, Agent or Firm:
YOGO PATENT & TRADEMARK AGENCY LIMITED COMPANY (CN)
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