Title:
A CLASS OF IMIDAZOLIDINOPYRIMIDONE COMPOUNDS AND USE THEREOF IN TREATMENT OF HSCLPP-MEDIATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/257581
Kind Code:
A1
Abstract:
The present invention relates to the use of a class of imidazolidinopyrimidone compounds, or a pharmaceutically acceptable salt, a hydrate or a crystal form thereof in the treatment of human caseinolytic protease P (HsClpP) mediated diseases, and belongs to the field of chemical medicine. The compounds have a significant activity in regulating and controlling HsClpP and can be used for treating related diseases mediated by HsClpP.
Inventors:
LUO YOUFU (CN)
YANG TAO (CN)
YANG TAO (CN)
Application Number:
PCT/CN2022/085402
Publication Date:
December 15, 2022
Filing Date:
April 06, 2022
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07D471/14; A61K31/519; A61P35/00
Domestic Patent References:
| WO2018031987A1 | 2018-02-15 | |||
| WO2018090939A1 | 2018-05-24 | |||
| WO2016123571A1 | 2016-08-04 | |||
| WO2019227240A1 | 2019-12-05 | |||
| WO2020172485A1 | 2020-08-27 |
Foreign References:
| CN109906227A | 2019-06-18 |
Other References:
HUANG JIASHENG, ZHANG JIANGNAN, LUO BAOZHU, QIAO WENLIANG, QIU ZHIQIANG, SONG RAO, DAI ZHENGYI, SUI JING, XU XIN, RUAN SHIHUA, LI : "Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 11, 9 June 2022 (2022-06-09), US , pages 7629 - 7655, XP093012346, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c02071
LUO BAOZHU, MA YU, ZHOU YUANZHENG, ZHANG NANNAN, LUO YOUFU: "Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 4, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 968 - 981, XP093012562, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2021.01.007
LUO BAOZHU, MA YU, ZHOU YUANZHENG, ZHANG NANNAN, LUO YOUFU: "Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 4, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 968 - 981, XP093012562, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2021.01.007
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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