Title:
CLASS OF PHENYLCARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/120235
Kind Code:
A1
Abstract:
The present invention relates to a class of phenylcarboxylic acid derivatives, a preparation method therefor and a use thereof, more specifically relating to a class of phenylcarboxylic acid derivatives as shown in formula I, a preparation method therefor, and a use thereof in the preparation a drug for the prevention and/or treatment of cerebral ischemia, hypoglycemia- or hypoxia-induced brain damage and/or neurological abnormalities. The structure of formula I is as shown left: (I).
Inventors:
ZHAO WEIMIN (CN)
ZHANG HAIYAN (CN)
QIN JUNJUN (CN)
WU LEI (CN)
WANG HONGMIN (CN)
FENG HONGXUAN (CN)
ZHANG RUJUN (CN)
WANG WEI (CN)
SHAO XINGCHENG (CN)
TAO LINGXUE (CN)
DING XUN (CN)
ZHANG HAIYAN (CN)
QIN JUNJUN (CN)
WU LEI (CN)
WANG HONGMIN (CN)
FENG HONGXUAN (CN)
ZHANG RUJUN (CN)
WANG WEI (CN)
SHAO XINGCHENG (CN)
TAO LINGXUE (CN)
DING XUN (CN)
Application Number:
PCT/CN2018/122227
Publication Date:
June 27, 2019
Filing Date:
December 20, 2018
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07C59/52; C07C59/64; C07C59/90; C07C69/73; C07C235/34; A61K31/165; A61K31/192; A61K31/216; A61P25/00; C07C67/08; C07C231/02
Domestic Patent References:
| WO2008028314A1 | 2008-03-13 |
Foreign References:
| JP2000256259A | 2000-09-19 | |||
| CN103804186A | 2014-05-21 | |||
| CN102030648A | 2011-04-27 |
Other References:
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BIANCHI, MARIO: "Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic aci- ds", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, 31 December 1988 (1988-12-31), pages 45 - 52, XP023871066, ISSN: 0223-5234
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BOZZINI, TIZIANA: "Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 24, 30 October 2013 (2013-10-30), XP028796491, ISSN: 0968-0896
MURAKAMI, A.: "Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccha- ride and interferon- gamma", CANCER LETTERS, vol. 157, no. 1, 31 December 2000 (2000-12-31), XP002749981, ISSN: 0304-3835
JAYAPRAKASAM, BOLLEDDULA: "Total synthesis and biological evaluation of (+)- and (-)-butyl ester of rosmarinic acidlmpact of Alkyl Esters of Caffeic and Ferulic Acids on Tumor Cell Proliferation, Cyclooxygenase Enzyme, and Lipid Peroxidation", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 54, no. 15, 1 July 2006 (2006-07-01), ISSN: 0021-8561
ETZENHOUSER, B.: "Mechanism of toxicity of esters of Caffeic and dihydro- caffeic acids", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, no. 1, 31 December 2001 (2001-12-31), pages 199 - 209, XP055621451, ISSN: 0968-0896
ZYMALKOWSKI, FELIX: "Reduction of beta -benzoylpropionic acids from resorci- nols", ARCHIV DER PHARMAZIE, vol. 299, no. 6, 30 June 1966 (1966-06-30), Weinheim, Germany, pages 545 - 559, ISSN: 0365-6233
IMOTO , HIROSHI: "Studies on non-thiazolidinedione antidiabetic agents. 3. Preparation and biological activity of the metabolites of TAK-559", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 52, no. 1, 31 January 2004 (2004-01-31), pages 120 - 124, XP055621457, ISSN: 0009-2363
HORNING, E. C.: "Glyoxylate Cyclizations. Methoxybenzsuberenes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 73, 31 December 1951 (1951-12-31), pages 5830, XP002688722, ISSN: 0002-7863
BIANCHI, MARIO: "Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic aci- ds", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, 31 December 1988 (1988-12-31), pages 45 - 52, XP023871066, ISSN: 0223-5234
DATABASE Registry CAS; 20 April 2011 (2011-04-20), retrieved from STN Database accession no. 1282910-05-7 R
DATABASE Registry CAS; 22 April 2011 (2011-04-22), retrieved from STN Database accession no. 1283958-34-8
DATABASE Registry CAS; 6 June 2008 (2008-06-06), retrieved from STN Database accession no. 1026002-61-8
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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