Title:
CLASS OF PRMT5 INHIBITORS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/002377
Kind Code:
A1
Abstract:
Provided is a class of compounds with methyltransferase inhibitory activity. Specifically, provided is a class of compounds with PRMT5 inhibitory activity. The compounds can be used for preparing a pharmaceutical composition for treating PRMT5 activity-related diseases. (I)
Inventors:
WANG LONG (CN)
WU HAIPING (CN)
MI YUAN (CN)
LIU YILIN (CN)
FU XINGNIAN (CN)
WANG MENG (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
WU HAIPING (CN)
MI YUAN (CN)
LIU YILIN (CN)
FU XINGNIAN (CN)
WANG MENG (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
Application Number:
PCT/CN2023/105594
Publication Date:
January 04, 2024
Filing Date:
July 03, 2023
Export Citation:
Assignee:
CYTOSINLAB THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/506; A61P35/00; C07D401/12; C07D401/14; C07D417/12; C07D487/04; C07D491/04; C07D519/00
Domestic Patent References:
WO2022115377A1 | 2022-06-02 | |||
WO2021163344A1 | 2021-08-19 | |||
WO2021127166A1 | 2021-06-24 | |||
WO2022169948A1 | 2022-08-11 | |||
WO2022256806A1 | 2022-12-08 |
Foreign References:
KR20090063869A | 2009-06-18 |
Other References:
DATABASE Registry 29 August 2022 (2022-08-29), ANONYMOUS : "Furo[3,4-c]quinoline-8-carboxamide, 4-amino-N-[2,3-dihydro-6-(1,2,3,6-tetrahydro-4-pyridinyl)-3-benzofuranyl]- 1,3-dihydro-N-methyl- (CA INDEX NAME)", XP093123861, retrieved from STNext Database accession no. 2814523-89-0
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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