Title:
CLASSIFICATION OF THYROID FOLLICULAR NEOPLASIA BASED ON MRNA EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2011/079846
Kind Code:
A3
Abstract:
The present invention relates to molecular classifiers based on specific m RNA expression patterns which distinguish the malignant and benign subtypes of thyroid follicular neoplasia; follicular thyroid carcinoma and follicular thyroid adenoma. The invention further relates to methods for diagnosing thyroid follicular neoplasia in samples from thyroid nodules to reduce the number of diagnostic operations and expediting surgery for individuals with a malignant nodule. Among the genes analysed are T0P2A, RRM2, PBK, ANLN, NR4A1, FOSB, EGR2 and CTGF.
Inventors:
ROSSING MARIA (DK)
NIELSEN FINN CILIUS (DK)
BENNEDBAEK FINN NOE (DK)
BORUP-HELWEG-LARSEN REHANNAH HOLGA ANDREA (DK)
NIELSEN FINN CILIUS (DK)
BENNEDBAEK FINN NOE (DK)
BORUP-HELWEG-LARSEN REHANNAH HOLGA ANDREA (DK)
Application Number:
PCT/DK2010/050358
Publication Date:
August 18, 2011
Filing Date:
December 23, 2010
Export Citation:
Assignee:
RIGSHOSPITALET (DK)
HERLEV HOSPITAL (DK)
ROSSING MARIA (DK)
NIELSEN FINN CILIUS (DK)
BENNEDBAEK FINN NOE (DK)
BORUP-HELWEG-LARSEN REHANNAH HOLGA ANDREA (DK)
HERLEV HOSPITAL (DK)
ROSSING MARIA (DK)
NIELSEN FINN CILIUS (DK)
BENNEDBAEK FINN NOE (DK)
BORUP-HELWEG-LARSEN REHANNAH HOLGA ANDREA (DK)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2009026605A2 | 2009-03-05 | |||
| WO2010056374A2 | 2010-05-20 | |||
| WO2010056931A1 | 2010-05-20 |
Other References:
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FRYKNAS MARTEN ET AL: "Molecular markers for discrimination of benign and malignant follicular thyroid tumors", TUMOR BIOLOGY, vol. 27, no. 4, 2006, pages 211 - 220, XP009132675, ISSN: 1010-4283
PRASAD NIJAGUNA B ET AL: "Identification of genes differentially expressed in benign versus malignant thyroid tumors.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 JUN 2008 LNKD- PUBMED:18519760, vol. 14, no. 11, 1 June 2008 (2008-06-01), pages 3327 - 3337, XP002629184, ISSN: 1078-0432
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DENNING KAREN M ET AL: "A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples", MODERN PATHOLOGY, vol. 20, no. 10, October 2007 (2007-10-01), pages 1095 - 1102, XP002579797, ISSN: 0893-3952
GRIFFITH O L ET AL: "Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US LNKD- DOI:10.1200/JCO.2006.06.7330, vol. 24, no. 31, 1 November 2006 (2006-11-01), pages 5043 - 5051, XP002499803, ISSN: 0732-183X
WEBER FRANK ET AL: "Genetic classification of benign and malignant thyroid follicular neoplasia based on a three-gene combination.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM MAY 2005 LNKD- PUBMED:15713710, vol. 90, no. 5, May 2005 (2005-05-01), pages 2512 - 2521, XP002579798, ISSN: 0021-972X
LEE ANDREA ET AL: "Expression of DNA topoisomerase IIalpha in thyroid neoplasia", MODERN PATHOLOGY, vol. 13, no. 4, April 2000 (2000-04-01), pages 396 - 400, XP002629185, ISSN: 0893-3952
BORUP REHANNAH ET AL: "Molecular signatures of thyroid follicular neoplasia", ENDOCRINE-RELATED CANCER, JOURNAL OF ENDOCRINOLOGY LTD., BRISTOL, GB, vol. 17, no. 3, 1 September 2010 (2010-09-01), pages 691 - 708, XP009142900, ISSN: 1351-0088
WIKMAN H ET AL: "Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array", ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 21, no. 37, 22 August 2002 (2002-08-22), pages 5804 - 5813, XP002309222, ISSN: 0950-9232, DOI: DOI:10.1038/SJ.ONC.1205726
FRYKNAS MARTEN ET AL: "Molecular markers for discrimination of benign and malignant follicular thyroid tumors", TUMOR BIOLOGY, vol. 27, no. 4, 2006, pages 211 - 220, XP009132675, ISSN: 1010-4283
PRASAD NIJAGUNA B ET AL: "Identification of genes differentially expressed in benign versus malignant thyroid tumors.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 JUN 2008 LNKD- PUBMED:18519760, vol. 14, no. 11, 1 June 2008 (2008-06-01), pages 3327 - 3337, XP002629184, ISSN: 1078-0432
CHEN ET AL: "An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines", CANCER LETTERS, NEW YORK, NY, US LNKD- DOI:10.1016/J.CANLET.2005.01.039, vol. 231, no. 2, 18 January 2006 (2006-01-18), pages 192 - 205, XP005255918, ISSN: 0304-3835
"Affymetrix GeneChip Human Genome U133 Array Set HG-U133A", GEO,, 11 March 2002 (2002-03-11), XP002254749
TAKANO T ET AL: "Decreased relative expression level of trefoil factor 3 mRNA to galectin-3 mRNA distinguishes thyroid follicular carcinoma from adenoma", CANCER LETTERS, NEW YORK, NY, US LNKD- DOI:10.1016/J.CANLET.2004.07.004, vol. 219, no. 1, 28 February 2005 (2005-02-28), pages 91 - 96, XP004733781, ISSN: 0304-3835
KRAUSE KERSTIN ET AL: "TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 93, no. 4, April 2008 (2008-04-01), pages 1390 - 1393, XP002579796, ISSN: 0021-972X
DENNING KAREN M ET AL: "A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples", MODERN PATHOLOGY, vol. 20, no. 10, October 2007 (2007-10-01), pages 1095 - 1102, XP002579797, ISSN: 0893-3952
GRIFFITH O L ET AL: "Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US LNKD- DOI:10.1200/JCO.2006.06.7330, vol. 24, no. 31, 1 November 2006 (2006-11-01), pages 5043 - 5051, XP002499803, ISSN: 0732-183X
WEBER FRANK ET AL: "Genetic classification of benign and malignant thyroid follicular neoplasia based on a three-gene combination.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM MAY 2005 LNKD- PUBMED:15713710, vol. 90, no. 5, May 2005 (2005-05-01), pages 2512 - 2521, XP002579798, ISSN: 0021-972X
LEE ANDREA ET AL: "Expression of DNA topoisomerase IIalpha in thyroid neoplasia", MODERN PATHOLOGY, vol. 13, no. 4, April 2000 (2000-04-01), pages 396 - 400, XP002629185, ISSN: 0893-3952
BORUP REHANNAH ET AL: "Molecular signatures of thyroid follicular neoplasia", ENDOCRINE-RELATED CANCER, JOURNAL OF ENDOCRINOLOGY LTD., BRISTOL, GB, vol. 17, no. 3, 1 September 2010 (2010-09-01), pages 691 - 708, XP009142900, ISSN: 1351-0088
WIKMAN H ET AL: "Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array", ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 21, no. 37, 22 August 2002 (2002-08-22), pages 5804 - 5813, XP002309222, ISSN: 0950-9232, DOI: DOI:10.1038/SJ.ONC.1205726
Attorney, Agent or Firm:
HØIBERG A/S (Copenhagen K, DK)
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