Title:
CO-AMORPHOUS SUBSTANCE OF CELECOXIB AND PREGABALIN AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/218930
Kind Code:
A1
Abstract:
Provided are a co-amorphous substance of celecoxib and pregabalin and a preparation method therefor. The co-amorphous substance, especially the co-amorphous substance, of which the molar ratio of celecoxib to pregabalin is 2:1, is stable in structure, thereby improving the water solubility of celecoxib and providing a convenient physical form for combined administration of celecoxib and pregabalin.
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Inventors:
LUO HUAN (CN)
LU PING (CN)
CHEN YEMING (CN)
JIANG YU (CN)
LU PING (CN)
CHEN YEMING (CN)
JIANG YU (CN)
Application Number:
PCT/CN2021/090017
Publication Date:
November 04, 2021
Filing Date:
April 26, 2021
Export Citation:
Assignee:
NHWA PHARMA CORP (CN)
SUZHOU NHWA PHARMACEUTICAL RES CO LTD (CN)
SUZHOU NHWA PHARMACEUTICAL RES CO LTD (CN)
International Classes:
A61K31/197; C07D231/12; A61K31/635; A61P25/02; A61P25/04; A61P25/06; A61P29/00; C07C229/08
Domestic Patent References:
| WO2004078163A2 | 2004-09-16 |
Foreign References:
| EP2325172A1 | 2011-05-25 | |||
| CN109336816A | 2019-02-15 | |||
| CN1673212A | 2005-09-28 | |||
| CN105646353A | 2016-06-08 |
Other References:
KE XUE-RU, LEI BO, CAO XING-HUA, XU QING-BANG: "The Clinical Study of Fibromyalgia Treated with Pregabalin , Celecoxib and Their Comination", CHINESE JOURNAL OF PAIN MEDICINE, vol. 19, no. 4, 31 December 2013 (2013-12-31), pages 212 - 215, XP009531438, ISSN: 1006-9852
LI DUANXIU, KONG MINMIN, LI JIONG, DENG ZONGWU, ZHANG HAILU: "Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals", CRYSTENGCOMM, vol. 20, no. 35, 1 January 2018 (2018-01-01), pages 5112 - 5118, XP055862445, DOI: 10.1039/C8CE01106K
CARLO LUCA ROMANò ; DELIA ROMANò ; CRISTINA BONORA ; GIUSEPPE MINEO: "Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain", JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY ; OFFICIAL JOURNAL OF THE ITALIAN SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY, SPRINGER-VERLAG, MI, vol. 10, no. 4, 18 November 2009 (2009-11-18), Mi , pages 185 - 191, XP019743999, ISSN: 1590-9999, DOI: 10.1007/s10195-009-0077-z
LI DUANXIU, KONG MINMIN, LI JIONG, DENG ZONGWU, ZHANG HAILU: "Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals", CRYSTENGCOMM, vol. 20, no. 35, 1 January 2018 (2018-01-01), pages 5112 - 5118, XP055862445, DOI: 10.1039/C8CE01106K
CARLO LUCA ROMANò ; DELIA ROMANò ; CRISTINA BONORA ; GIUSEPPE MINEO: "Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain", JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY ; OFFICIAL JOURNAL OF THE ITALIAN SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY, SPRINGER-VERLAG, MI, vol. 10, no. 4, 18 November 2009 (2009-11-18), Mi , pages 185 - 191, XP019743999, ISSN: 1590-9999, DOI: 10.1007/s10195-009-0077-z
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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