Title:
COATED MICRONEEDLE HAVING MULTI-LAYER STRUCTURE, PREPARATION METHOD THEREFOR, AND MICRONEEDLE PATCH COMPRISING COATED MICRONEEDLE
Document Type and Number:
WIPO Patent Application WO/2022/048682
Kind Code:
A1
Abstract:
Disclosed in the present invention are a coated microneedle having a multi-layer structure, comprising: a base, a needle tip located on the base, and a functional coating; the functional coating comprises a content containing a water-soluble polymer material and an active ingredient, and a sustained-release layer wrapping the content; and the needle tip is enveloped by the sustained-release layer. The coated microneedle can prevent rapid dissolution of a drug-containing matrix, prevent active ingredients from exuding along with tissues of a site of action, and increase a drug intake amount. Also disclosed in the present invention are a preparation method for the coated microneedle and a microneedle patch comprising the coated microneedle.
Inventors:
GAO YUNHUA (CN)
ZHOU ZEQUAN (CN)
ZHANG SUOHUI (CN)
ZHOU ZEQUAN (CN)
ZHANG SUOHUI (CN)
Application Number:
PCT/CN2021/116904
Publication Date:
March 10, 2022
Filing Date:
September 07, 2021
Export Citation:
Assignee:
TECHNICAL INST OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K8/02; A61M37/00; A61K8/73; A61K9/00; A61K9/70; A61K47/36
Foreign References:
| CN104921961A | 2015-09-23 | |||
| CN110870846A | 2020-03-10 | |||
| CN110917176A | 2020-03-27 | |||
| CN104338235A | 2015-02-11 |
Other References:
ZHOU ZEQUAN, ZHANG SUOHUI, YANG GUOZHONG, GAO YUNHUA: "Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles: rhIFNα-1b example", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 16, no. 5, 1 September 2021 (2021-09-01), NL , pages 612 - 622, XP055907857, ISSN: 1818-0876, DOI: 10.1016/j.ajps.2021.05.002
PARK SEOK, KIM MIN, BAEK SEUNG-KI, PARK JUNG-HWAN, CHOI SEONG-O: "Spray-Formed Layered Polymer Microneedles for Controlled Biphasic Drug Delivery", POLYMERS, vol. 11, no. 2, 20 February 2019 (2019-02-20), pages 1 - 13, XP055907863, DOI: 10.3390/polym11020369
PARK SEOK, KIM MIN, BAEK SEUNG-KI, PARK JUNG-HWAN, CHOI SEONG-O: "Spray-Formed Layered Polymer Microneedles for Controlled Biphasic Drug Delivery", POLYMERS, vol. 11, no. 2, 20 February 2019 (2019-02-20), pages 1 - 13, XP055907863, DOI: 10.3390/polym11020369
Attorney, Agent or Firm:
BEIJING JANLEA PATENT AGENCY CO., LTD. (CN)
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