Title:
COILED-COIL FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2023/055045
Kind Code:
A1
Abstract:
The present invention relates to: a polypeptide comprising a self-assembling domain; a fusion protein comprising the polypeptide; a nucleic acid molecule encoding same; or a composition comprising the polypeptide, fusion protein or nucleic acid molecule. A fusion protein or a composition of the present invention is combined or loaded with various drug moieties (proteins, antibody fragments and the like) according to desired purposes so as to implement same in module form and combine same through self-combination, and thus can achieve improved combination ability with respect to a target and/or increased drug activity.
Inventors:
LEE DAE-HEE (KR)
LEE JEONG EUN (KR)
LIM SUNG IN (KR)
SHIN GOEUN (KR)
KWON HYUK TAEK (KR)
YANG I JI (KR)
LEE JEONG EUN (KR)
LIM SUNG IN (KR)
SHIN GOEUN (KR)
KWON HYUK TAEK (KR)
YANG I JI (KR)
Application Number:
PCT/KR2022/014508
Publication Date:
April 06, 2023
Filing Date:
September 28, 2022
Export Citation:
Assignee:
NBIOS INC (KR)
International Classes:
A61K47/42; A61K38/00; A61K47/64; A61P35/00; C07K1/16; C07K14/47; C07K14/705; C12N15/70
Foreign References:
| US10610514B2 | 2020-04-07 | |||
| US6316652B1 | 2001-11-13 | |||
| US6274552B1 | 2001-08-14 | |||
| US6271359B1 | 2001-08-07 | |||
| US6253872B1 | 2001-07-03 | |||
| US6139865A | 2000-10-31 | |||
| US6131570A | 2000-10-17 | |||
| US6120751A | 2000-09-19 | |||
| US6071495A | 2000-06-06 | |||
| US6060082A | 2000-05-09 | |||
| US6048736A | 2000-04-11 | |||
| US6039975A | 2000-03-21 | |||
| US6004534A | 1999-12-21 | |||
| US5985307A | 1999-11-16 | |||
| US5972366A | 1999-10-26 | |||
| US5900252A | 1999-05-04 | |||
| US5840674A | 1998-11-24 | |||
| US5759542A | 1998-06-02 | |||
| US5709874A | 1998-01-20 |
Other References:
N. M. WALAVALKAR, N. GORDON, D. C. WILLIAMS: "Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66 )", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 5, 1 February 2013 (2013-02-01), US , pages 3419 - 3427, XP055236750, ISSN: 0021-9258, DOI: 10.1074/jbc.M112.431346
UTTERSTRÖM JOHANNA, NAEIMIPOUR SAJJAD, SELEGÅRD ROBERT, AILI DANIEL: "Coiled coil-based therapeutics and drug delivery systems", ADVANCED DRUG DELIVERY REVIEWS, vol. 170, 1 March 2021 (2021-03-01), Amsterdam , NL , pages 26 - 43, XP055911868, ISSN: 0169-409X, DOI: 10.1016/j.addr.2020.12.012
MIN YOUNG KIM, INSUNG NA, JI SOOK KIM, SEUNG HAN SON, SUNGWOO CHOI, SEOL EUI LEE, JI-HUN KIM, KISEOK JANG, GIL ALTEROVITZ, YU CHEN: "Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2", SCIENCE ADVANCES, vol. 5, no. 11, 1 November 2019 (2019-11-01), pages eaav9810 - 20, XP055714849, DOI: 10.1126/sciadv.aav9810
MCFARLANE, A.A. ; ORRISS, G.L. ; STETEFELD, J.: "The use of coiled-coil proteins in drug delivery systems", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 625, no. 1-3, 25 December 2009 (2009-12-25), NL , pages 101 - 107, XP026762252, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2009.05.034
ZORZI ET AL., MEDCHEMCOMM., vol. 10, no. 7, 1 July 2019 (2019-07-01), pages 1068 - 1081
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
MANIATIS ET AL.: "Molecular Cloning, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1994, JOHN, WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
UTTERSTRÖM JOHANNA, NAEIMIPOUR SAJJAD, SELEGÅRD ROBERT, AILI DANIEL: "Coiled coil-based therapeutics and drug delivery systems", ADVANCED DRUG DELIVERY REVIEWS, vol. 170, 1 March 2021 (2021-03-01), Amsterdam , NL , pages 26 - 43, XP055911868, ISSN: 0169-409X, DOI: 10.1016/j.addr.2020.12.012
MIN YOUNG KIM, INSUNG NA, JI SOOK KIM, SEUNG HAN SON, SUNGWOO CHOI, SEOL EUI LEE, JI-HUN KIM, KISEOK JANG, GIL ALTEROVITZ, YU CHEN: "Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2", SCIENCE ADVANCES, vol. 5, no. 11, 1 November 2019 (2019-11-01), pages eaav9810 - 20, XP055714849, DOI: 10.1126/sciadv.aav9810
MCFARLANE, A.A. ; ORRISS, G.L. ; STETEFELD, J.: "The use of coiled-coil proteins in drug delivery systems", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 625, no. 1-3, 25 December 2009 (2009-12-25), NL , pages 101 - 107, XP026762252, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2009.05.034
ZORZI ET AL., MEDCHEMCOMM., vol. 10, no. 7, 1 July 2019 (2019-07-01), pages 1068 - 1081
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
MANIATIS ET AL.: "Molecular Cloning, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1994, JOHN, WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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