Title:
COLCHICINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2005007076
Kind Code:
B1
Abstract:
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group - C(O)-(CHR4)m-AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond; R1 is substituted phenyl or substituted benzoyl; optionally substituted cycloalkyl of 3-7 carbons; optionally substituted naphtyl; an optionally substituted imide ring; an optionally substituted 5 or 6 member heterocycle with at least one N, S, or O in the ring; or an optionally substituted fused heterocyclic or fused carboxyclic ring system; R2 (at the 2-position of the A ring) is methoxy, hydroxy, or methylenedioxy when taken together with R3; R3 (at the 3-position of the A ring) is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R2; and R4 is H or is H or methyl when m is 1. Also dimers of such compounds are disclosed. When combined with suitable pharmaceutical excipients, these compounds are useful for treating various types of cancer.
Inventors:
YANG LI-XI (US)
Application Number:
PCT/US2004/011593
Publication Date:
June 16, 2005
Filing Date:
April 14, 2004
Export Citation:
Assignee:
CALIFORNIA PACIFIC MED CENTER (US)
CATHOLIC HEALTHCARE WEST DOING (US)
YANG LI-XI (US)
CATHOLIC HEALTHCARE WEST DOING (US)
YANG LI-XI (US)
International Classes:
C07C323/41; C07C323/42; C07C323/60; C07D295/15; C07H5/06; (IPC1-7): A61K31/4439; A61K31/433; A61K31/403; A61K31/155; A61K31/175
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