Title:
COLD-ADAPTED EQUINE INFLUENZA VIRUSES
Document Type and Number:
WIPO Patent Application WO2001074386
Kind Code:
A3
Abstract:
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus or other infectious agents utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to an infectious agent, as well as using a therapeutic composition as a treatment for an animal that has been recently infected with an infectious agent leading to respiratory disease, or is likely to be subsequently exposed to such an agent in a few days whereby the therapeutic composition reduces such respiratory disease, even in the absence of antibody-mediated immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.
Inventors:
DOWLING PATRICIA W (US)
YOUNGNER JULIUS S (US)
YOUNGNER JULIUS S (US)
Application Number:
PCT/US2001/008968
Publication Date:
May 23, 2002
Filing Date:
March 21, 2001
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
DOWLING PATRICIA W (US)
YOUNGNER JULIUS S (US)
DOWLING PATRICIA W (US)
YOUNGNER JULIUS S (US)
International Classes:
A01K13/00; A61K39/145; A61P11/00; A61P31/04; A61P31/12; A61P31/16; C12N7/08; (IPC1-7): A61K39/145; A61P31/16; A61P31/04
Domestic Patent References:
| WO2000009702A1 | 2000-02-24 |
Other References:
MAYR A: "[Respiratory infectious diseases in horses]. Respiratorische Infektionskrankheiten beim Pferd.", TIERARZTLICHE PRAXIS. SUPPLEMENT, (1987) 2 1-4. REF: 0, 1987, XP001015771
TIMONEY P J: "Equine influenza.", COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 19, no. 3, 1996, pages 205 - 211, XP001015825, ISSN: 0147-9571
TIMONEY P J: "Equine influenza.", COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 19, no. 3, 1996, pages 205 - 211, XP001015825, ISSN: 0147-9571
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