Title:
COLLAGENOUS FIBER COMPOSITE MEMBRANE FOR REPAIRING NERVE INJURIES
Document Type and Number:
WIPO Patent Application WO/2024/082416
Kind Code:
A1
Abstract:
The present invention relates to a collagenous fiber composite membrane for repairing nerve injuries. The collagenous fiber composite membrane comprises: an anti-adhesion layer, an elastic connection layer chemically cross-linked with the anti-adhesion layer, and a regeneration-promoting layer chemically cross-linked with the elastic connection layer, wherein the anti-adhesion layer and the regeneration-promoting layer can slide relative to each other within 20% of the lengths thereof along the axial direction. The collagenous fiber composite membrane of the present invention is divided into the anti-adhesion layer and the regeneration-promoting layer by means of the elastic connection layer. The anti-adhesion layer, which is made from type I collagen by means of mold casting, has a smooth surface, and it is difficult for cells to attach thereto, so that abnormally activated fibroblasts can be prevented from deposition in an adhesion zone; the regeneration-promoting layer, which is made from type I collagen by means of electrospinning, has an axial orientation, and supporting cells of the nerves can attach to the nanofiber structure for axial regeneration; and the relative sliding between the anti-adhesion layer and the regeneration-promoting layer can avoid abnormal pain caused by nerve stretching.
Inventors:
QIAN YUN (CN)
YAN ZHIWEN (CN)
FAN CUNYI (CN)
YAN ZHIWEN (CN)
FAN CUNYI (CN)
Application Number:
PCT/CN2022/139668
Publication Date:
April 25, 2024
Filing Date:
December 16, 2022
Export Citation:
Assignee:
SHANGHAI SIXTH PEOPLE’S HOSPITAL (CN)
International Classes:
A61L27/40; A61L27/22; A61L27/24; A61L27/50
Domestic Patent References:
| WO2018225076A1 | 2018-12-13 |
Foreign References:
| CN103920194A | 2014-07-16 | |||
| CN109224133A | 2019-01-18 | |||
| CN101912318A | 2010-12-15 | |||
| CN107205809A | 2017-09-26 | |||
| CN109260520A | 2019-01-25 | |||
| CN114558173A | 2022-05-31 | |||
| EP1604696A1 | 2005-12-14 | |||
| US20130095167A1 | 2013-04-18 |
Attorney, Agent or Firm:
SHANGHAI SHENXIN LAW FIRM (CN)
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