Title:
COLLOIDAL MOF FOR ARTERIOSCLEROSIS TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/160700
Kind Code:
A1
Abstract:
Provided herein are compositions and methods for treating cardiovasculardisease, particularly those known to be caused by endothelial dysfunctions due to nitricoxide (NO) deficiency in patients.The colloidal coordination compounds, including, for example,copper doped Zeolitic Imidazolate Framework 8(ZIF-8), can convert blood borne s-nitrosothiols into nitric oxide.The disintegration of the colloidal coordination compounds, including copper doped ZIF-8, can occur slowly into blood plasma, which causes a sustained and controlled conversion of s-nitrosothiols into nitric oxide. Since the Zeolitic Imidazolate Frameworks (ZIFs) disintegrates under acidic pH, the slowly-degrading copper-doped ZIF-8 can also be used as a targeted and sustained colloidal drug carrier for acidic atherosclerotic plaques.The colloidal coordination compounds can be used for targeted delivery of metal ions,organic molecules, or a pay Load, including drugs or formulations with intrinsic bioactivity resulting from structural features.
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Inventors:
OLDENBURG SEBASTIAN BEYER (CN)
TSANG CHUNG YIN (CN)
CHU CHEE MAN (CN)
CHEUNG CHUNG YIN (CN)
TSANG CHUNG YIN (CN)
CHU CHEE MAN (CN)
CHEUNG CHUNG YIN (CN)
Application Number:
PCT/CN2023/078423
Publication Date:
August 31, 2023
Filing Date:
February 27, 2023
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
International Classes:
A61K33/34; A61K31/30; A61K31/315; A61K33/30; A61P9/10
Foreign References:
| JPH11319538A | 1999-11-24 | |||
| US20020136781A1 | 2002-09-26 | |||
| KR20060110590A | 2006-10-25 | |||
| US20050084412A1 | 2005-04-21 | |||
| GB130709A | 1919-08-06 |
Other References:
TROYANO JAVIER, CARNÉ-SÁNCHEZ ARNAU, AVCI CIVAN, IMAZ INHAR, MASPOCH DANIEL: "Colloidal metal–organic framework particles: the pioneering case of ZIF-8", CHEMICAL SOCIETY REVIEWS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 48, no. 23, 25 November 2019 (2019-11-25), UK , pages 5534 - 5546, XP093088507, ISSN: 0306-0012, DOI: 10.1039/C9CS00472F
REN QINFENG, LUO YONGSONG, LI SUQIN, ZHANG YONGGANG, LI JIALIN: "Copper colloid oxidized by air to prepare cuprous oxide nanoparticles", HUAZHONG SHIFAN DAXUE XUEBAO. ZIRAN KEXUE BAN - JOURNAL OFCENTRAL CHINA NORMAL UNIVERSITY, XX, WUHAN, CN, vol. 41, no. 1, 31 March 2007 (2007-03-31), CN , pages 70 - 74, XP093088520, ISSN: 1000-1190
REN QINFENG, LUO YONGSONG, LI SUQIN, ZHANG YONGGANG, LI JIALIN: "Copper colloid oxidized by air to prepare cuprous oxide nanoparticles", HUAZHONG SHIFAN DAXUE XUEBAO. ZIRAN KEXUE BAN - JOURNAL OFCENTRAL CHINA NORMAL UNIVERSITY, XX, WUHAN, CN, vol. 41, no. 1, 31 March 2007 (2007-03-31), CN , pages 70 - 74, XP093088520, ISSN: 1000-1190
CHANGJOON KEUM; SANGWOO PARK; SANG‐YUP LEE: "Cancer‐Cell Imaging Using Copper‐Doped Zeolite Imidazole Framework‐8 Nanocrystals Exhibiting Oxidative Catalytic Activity", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 13, no. 18, 5 August 2018 (2018-08-05), Hoboken, USA, pages 2641 - 2648, XP072428785, ISSN: 1861-4728, DOI: 10.1002/asia.201800749
LAMB, DAVID J. ET AL.: "Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis", INT J EXP PATHOL., vol. 86, 31 December 2005 (2005-12-31), pages 247 - 255, XP071900595, DOI: 10.1111/j.0959-9673.2005.00432.x
TSANG CHUNG YIN, CHEUNG MATTHEW CHUNG YIN, BEYER SEBASTIAN: "Assessing the colloidal stability of copper doped ZIF-8 in water and serum", COLLOIDS AND SURFACES A : PHYSIOCHEMICAL AND ENGINEERINGS ASPECTS, ELSEVIER, AMSTERDAM, NL, vol. 656, 1 January 2023 (2023-01-01), AMSTERDAM, NL , pages 130452, XP093088525, ISSN: 0927-7757, DOI: 10.1016/j.colsurfa.2022.130452
REN QINFENG, LUO YONGSONG, LI SUQIN, ZHANG YONGGANG, LI JIALIN: "Copper colloid oxidized by air to prepare cuprous oxide nanoparticles", HUAZHONG SHIFAN DAXUE XUEBAO. ZIRAN KEXUE BAN - JOURNAL OFCENTRAL CHINA NORMAL UNIVERSITY, XX, WUHAN, CN, vol. 41, no. 1, 31 March 2007 (2007-03-31), CN , pages 70 - 74, XP093088520, ISSN: 1000-1190
REN QINFENG, LUO YONGSONG, LI SUQIN, ZHANG YONGGANG, LI JIALIN: "Copper colloid oxidized by air to prepare cuprous oxide nanoparticles", HUAZHONG SHIFAN DAXUE XUEBAO. ZIRAN KEXUE BAN - JOURNAL OFCENTRAL CHINA NORMAL UNIVERSITY, XX, WUHAN, CN, vol. 41, no. 1, 31 March 2007 (2007-03-31), CN , pages 70 - 74, XP093088520, ISSN: 1000-1190
CHANGJOON KEUM; SANGWOO PARK; SANG‐YUP LEE: "Cancer‐Cell Imaging Using Copper‐Doped Zeolite Imidazole Framework‐8 Nanocrystals Exhibiting Oxidative Catalytic Activity", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 13, no. 18, 5 August 2018 (2018-08-05), Hoboken, USA, pages 2641 - 2648, XP072428785, ISSN: 1861-4728, DOI: 10.1002/asia.201800749
LAMB, DAVID J. ET AL.: "Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis", INT J EXP PATHOL., vol. 86, 31 December 2005 (2005-12-31), pages 247 - 255, XP071900595, DOI: 10.1111/j.0959-9673.2005.00432.x
TSANG CHUNG YIN, CHEUNG MATTHEW CHUNG YIN, BEYER SEBASTIAN: "Assessing the colloidal stability of copper doped ZIF-8 in water and serum", COLLOIDS AND SURFACES A : PHYSIOCHEMICAL AND ENGINEERINGS ASPECTS, ELSEVIER, AMSTERDAM, NL, vol. 656, 1 January 2023 (2023-01-01), AMSTERDAM, NL , pages 130452, XP093088525, ISSN: 0927-7757, DOI: 10.1016/j.colsurfa.2022.130452
Attorney, Agent or Firm:
BEYOND TALENT PATENT AGENT FIRM (CN)
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