Title:
COMBINATION OF EGF/GHRP-6 FOR NEUROGENERATION OF CENTRAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO2006092106
Kind Code:
A3
Abstract:
The invention is intended to simulate neuroregeneration of the central nervous system following autoimmune damage. More specifically, the invention relates to the pharmaceutical combination comprising therapeutically-effective concentrations of epidermal growth factor and human growth hormone secretagogue hexapeptide, which is administered to a patient suffering from the symptoms of multiple sclerosis and neuromyelitis optica and which corrects demyelination caused by autoreactive cells in the central nervous system.
Inventors:
GARCIA DEL BARCO HERRERA DIANA (CU)
GUILLEN NIETO GERARDO ENRIQUE (CU)
BERLANGA ACOSTA JORGE AMADOR (CU)
FREYRE ALMEIDA FREYA DE LOS MI (CU)
CIBRIAN VERA DANAY (CU)
PENTON ARIAS EDUARDO (CU)
GUILLEN NIETO GERARDO ENRIQUE (CU)
BERLANGA ACOSTA JORGE AMADOR (CU)
FREYRE ALMEIDA FREYA DE LOS MI (CU)
CIBRIAN VERA DANAY (CU)
PENTON ARIAS EDUARDO (CU)
Application Number:
PCT/CU2006/000001
Publication Date:
December 14, 2006
Filing Date:
February 24, 2006
Export Citation:
Assignee:
CT INGENIERIA GENETICA BIOTECH (CU)
GARCIA DEL BARCO HERRERA DIANA (CU)
GUILLEN NIETO GERARDO ENRIQUE (CU)
BERLANGA ACOSTA JORGE AMADOR (CU)
FREYRE ALMEIDA FREYA DE LOS MI (CU)
CIBRIAN VERA DANAY (CU)
PENTON ARIAS EDUARDO (CU)
GARCIA DEL BARCO HERRERA DIANA (CU)
GUILLEN NIETO GERARDO ENRIQUE (CU)
BERLANGA ACOSTA JORGE AMADOR (CU)
FREYRE ALMEIDA FREYA DE LOS MI (CU)
CIBRIAN VERA DANAY (CU)
PENTON ARIAS EDUARDO (CU)
International Classes:
A61K38/08; A61K38/18; A61K38/25; A61P25/28
Domestic Patent References:
| WO2000030675A2 | 2000-06-02 |
Other References:
FRAGO LAURA M ET AL: "Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection", ENDOCRINOLOGY, vol. 143, no. 10, October 2002 (2002-10-01), pages 4113 - 4122, XP002395581, ISSN: 0013-7227
HARVEY STEVE ET AL: "Neural growth hormone: an update.", JOURNAL OF MOLECULAR NEUROSCIENCE : MN. FEB 2003, vol. 20, no. 1, February 2003 (2003-02-01), pages 1 - 14, XP009071227, ISSN: 0895-8696
SCHNEIDER HARALD JOERN ET AL: "Central effects of the somatotropic system.", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 149, no. 5, November 2003 (2003-11-01), pages 377 - 392, XP002395582, ISSN: 0804-4643
PLATA-SALAMAN C R: "EPIDERMAL GROWTH FACTOR AND THE NERVOUS SYSTEM", PEPTIDES, ELSEVIER, AMSTERDAM, US, vol. 12, no. 3, May 1991 (1991-05-01), pages 653 - 663, XP001181067, ISSN: 0196-9781
KNAPP PAMELA E ET AL: "Epidermal growth factor promotes oligodendrocyte process formation and regrowth after injury.", EXPERIMENTAL CELL RESEARCH. 10 JUN 2004, vol. 296, no. 2, 10 June 2004 (2004-06-10), pages 135 - 144, XP002395583, ISSN: 0014-4827
RAINETEAU OLIVIER ET AL: "Neurogenesis in hippocampal slice cultures", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 26, no. 2, June 2004 (2004-06-01), pages 241 - 250, XP002395584, ISSN: 1044-7431
KUHN H G ET AL: "Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 17, no. 15, 1997, pages 5820 - 5829, XP002229396, ISSN: 0270-6474
ARSENIJEVIC Y AND WEISS S: "Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neural precursors: Distinct actions from those of brain-derived neurotrophic factor", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 18, no. 6, 15 March 1998 (1998-03-15), pages 2118 - 2128, XP002146610, ISSN: 0270-6474
ROM POULSEN F ET AL: "Glutamate receptor antagonists and growth factors modulate dentate granule cell neurogenesis in organotypic, rat hippocampal slice cultures", BRAIN RESEARCH, AMSTERDAM, NL, vol. 1051, no. 1-2, 27 July 2005 (2005-07-27), pages 35 - 49, XP004984668, ISSN: 0006-8993
HARVEY STEVE ET AL: "Neural growth hormone: an update.", JOURNAL OF MOLECULAR NEUROSCIENCE : MN. FEB 2003, vol. 20, no. 1, February 2003 (2003-02-01), pages 1 - 14, XP009071227, ISSN: 0895-8696
SCHNEIDER HARALD JOERN ET AL: "Central effects of the somatotropic system.", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 149, no. 5, November 2003 (2003-11-01), pages 377 - 392, XP002395582, ISSN: 0804-4643
PLATA-SALAMAN C R: "EPIDERMAL GROWTH FACTOR AND THE NERVOUS SYSTEM", PEPTIDES, ELSEVIER, AMSTERDAM, US, vol. 12, no. 3, May 1991 (1991-05-01), pages 653 - 663, XP001181067, ISSN: 0196-9781
KNAPP PAMELA E ET AL: "Epidermal growth factor promotes oligodendrocyte process formation and regrowth after injury.", EXPERIMENTAL CELL RESEARCH. 10 JUN 2004, vol. 296, no. 2, 10 June 2004 (2004-06-10), pages 135 - 144, XP002395583, ISSN: 0014-4827
RAINETEAU OLIVIER ET AL: "Neurogenesis in hippocampal slice cultures", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 26, no. 2, June 2004 (2004-06-01), pages 241 - 250, XP002395584, ISSN: 1044-7431
KUHN H G ET AL: "Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 17, no. 15, 1997, pages 5820 - 5829, XP002229396, ISSN: 0270-6474
ARSENIJEVIC Y AND WEISS S: "Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neural precursors: Distinct actions from those of brain-derived neurotrophic factor", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 18, no. 6, 15 March 1998 (1998-03-15), pages 2118 - 2128, XP002146610, ISSN: 0270-6474
ROM POULSEN F ET AL: "Glutamate receptor antagonists and growth factors modulate dentate granule cell neurogenesis in organotypic, rat hippocampal slice cultures", BRAIN RESEARCH, AMSTERDAM, NL, vol. 1051, no. 1-2, 27 July 2005 (2005-07-27), pages 35 - 49, XP004984668, ISSN: 0006-8993
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