Title:
COMBINATION OF ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2022/102634
Kind Code:
A1
Abstract:
Provided are a pharmaceutical composition and a treatment method that are excellent in terms of antitumor effect and safety. A pharmaceutical composition and a treatment method characterized in that an antibody-drug conjugate, in which a drug linker shown by the formula (in the formula, A represents the binding site with the antibody) and an antibody are bonded by a thioether bond, is administered in combination with an SIRPα-CD47 interaction inhibitor such as an anti-SIRPα antibody, etc. Also, a pharmaceutical composition and a treatment method characterized in that the antibody-drug conjugate and an SIRPα-CD47 interaction inhibitor such as an anti-SIRPα antibody, etc., are administered in combination and used to treat a disease which is improved by the action of activating antitumor immunity.
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Inventors:
SUE MAYUMI (JP)
TSUBAKI TAKUYA (JP)
ISHIMOTO YOKO (JP)
TSUBAKI TAKUYA (JP)
ISHIMOTO YOKO (JP)
Application Number:
PCT/JP2021/041255
Publication Date:
May 19, 2022
Filing Date:
November 10, 2021
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K47/68; A61K31/4745; A61K39/395; A61K47/55; A61P35/00; A61P35/02; A61P43/00
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TAKENAKA ET AL., NAT IMMUNOL., vol. 12, no. 8, 2007, pages 1313 - 1323
MATOZAKI ET AL., J. BIOCHEM., vol. 6, no. 155, 2014, pages 335 - 344
OGITANI Y. ET AL., CLINICAL CANCER RESEARCH, vol. 22, no. 20, 2016, pages 5097 - 5108
OGITANI Y. ET AL., CANCER SCIENCE, vol. 107, 2016, pages 1039 - 1046
DOI T ET AL., LANCET ONCOL, vol. 18, 2017, pages 1512 - 22
TAKEGAWA N ET AL., INT. J. CANCER, vol. 141, 2017, pages 1682 - 1689
OGITANI Y. ET AL., CLINICAL CANCER RESEARCH, vol. 22, no. 20, 29 March 2016 (2016-03-29), pages 5097 - 5108
CELL DEATH AND DIFFERENTIATION, vol. 15, 2008, pages 751 - 761
MOLECULAR BIOLOGY OF THE CELL, vol. 15, December 2004 (2004-12-01), pages 5268 - 5282
BIO TECHNIQUES, vol. 28, January 2000 (2000-01-01), pages 162 - 165
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
HERMANSON, G. T: "Bioconjugate Techniques", 1996, ACADEMIC PRESS, pages: 56 - 136,456-493
BRUGGEMANN ET AL., J. EXP. MED., 1987, pages 1351 - 1361
KABAT: "Sequences of proteins of immunological interest", 1991
PAREKH ET AL., MABS, 2012, pages 310 - 318
ANGAL, MOLECULAR IMMUNOLOGY, 1993, pages 105 - 108
VAFA, METHODS, vol. 65, 2014, pages 114 - 126
TSUBAKI, INT. J. BIOL. MACROMOL, 2013, pages 139 - 147
NATURE REVIEWS IMMUNOLOGY., vol. 17, 2017, pages 97 - 111
CANCER RESEARCH, vol. 77, 2017, pages 2686 - 2698
ONCOIMMUNOLOGY, vol. 8, no. 4, 2019, pages e1565859
CLIN. INVEST., vol. 130, no. 1, 2020, pages 374 - 388
YANAGITA ET AL., JCI INSIGHT, vol. 1, no. 2, 2017, pages 1 - 15
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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