Title:
COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/138793
Kind Code:
A1
Abstract:
The present application addresses the problem of providing an effective cancer treatment method. Provided is a combination between: a compound represented by general formula (I-A) (in the formula, all signs represent the same as those set forth in the description), a pharmaceutically acceptable salt thereof, or a hydrate thereof; and an immune checkpoint inhibitor (e.g., anti-PD-1 antibody, etc.) and/or an EP4 receptor antagonist. The combination according to the present invention exhibits a strong antitumor effect and therefore is useful in cancer treatment.
Inventors:
TAKEDA KAZUHIKO (JP)
KOTANI TOHRU (JP)
ISAJI YUKI (JP)
KAWAGUCHI TAKAMASA (JP)
KOTANI TOHRU (JP)
ISAJI YUKI (JP)
KAWAGUCHI TAKAMASA (JP)
Application Number:
PCT/JP2021/047780
Publication Date:
June 30, 2022
Filing Date:
December 23, 2021
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K31/196; A61K31/341; A61K31/351; A61K31/40; A61K31/415; A61K31/416; A61K31/4164; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/4965; A61K45/06; A61P35/00; A61P43/00
Domestic Patent References:
| WO2016111347A1 | 2016-07-14 | |||
| WO2020262603A1 | 2020-12-30 |
Foreign References:
| JP2007513167A | 2007-05-24 | |||
| JP2002529455A | 2002-09-10 | |||
| JP2018515438A | 2018-06-14 | |||
| US20150004175A1 | 2015-01-01 | |||
| JP2015520738A | 2015-07-23 |
Other References:
BOJARSKA-DAHLIG H N: "IODO DERIVATIVES OF 5-METHYL-1-PHENYL- 1,2,3-TRIAZOLECARBOXYLIC ACID", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 80, no. 12, 1 January 1961 (1961-01-01), Amsterdam, NL , pages 1348 - 1356, XP055946117, ISSN: 0165-0513
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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