Title:
COMBINATION OF COMPONENTS FOR THE PREVENTION AND TREATMENT OF FRAILTY
Document Type and Number:
WIPO Patent Application WO/2012/091571
Kind Code:
A3
Abstract:
Composition comprising at least two components, more preferably at least three components, more preferably at least four components, selected from the group of (i) a nucleoside equivalent, (ii) an ω-3 polyunsaturated fatty acid selected from the group of DHA, DPA and EPA, (iii) a vitamin B, (iv) a phospholipid, (v) an antioxidant and (vi) a choline, with the proviso that at least component (i) or (iii) is present, for use in the prevention or treatment of frailty in a mammal, wherein frailty is determined by compliance with at least 2 criterions, preferably 3 criterions, selected from the group of muscle weakness, excessive feelings of exhaustion or fatigue, abnormally low physical activity, slow or unsteady gait, weight loss, and neurological dysfunction.
Inventors:
HAGEMAN ROBERT JOHAN JOSEPH (NL)
DE WILDE MATTHEUS CORNELIS (NL)
GROENENDIJK MARTINE (NL)
KAMPHUIS PATRICK JOSEPH GERARDUS HENDRIKUS (NL)
DE WILDE MATTHEUS CORNELIS (NL)
GROENENDIJK MARTINE (NL)
KAMPHUIS PATRICK JOSEPH GERARDUS HENDRIKUS (NL)
Application Number:
PCT/NL2011/050908
Publication Date:
September 07, 2012
Filing Date:
December 28, 2011
Export Citation:
Assignee:
NUTRICIA NV (NL)
HAGEMAN ROBERT JOHAN JOSEPH (NL)
DE WILDE MATTHEUS CORNELIS (NL)
GROENENDIJK MARTINE (NL)
KAMPHUIS PATRICK JOSEPH GERARDUS HENDRIKUS (NL)
HAGEMAN ROBERT JOHAN JOSEPH (NL)
DE WILDE MATTHEUS CORNELIS (NL)
GROENENDIJK MARTINE (NL)
KAMPHUIS PATRICK JOSEPH GERARDUS HENDRIKUS (NL)
International Classes:
A61K31/14; A23L33/00; A23L33/15; A61K31/202; A61K31/355; A61K31/375; A61K31/4415; A61K31/519; A61K31/683; A61K31/685; A61K31/7072; A61K31/714; A61K33/04; A61K45/06; A61P3/02; A61P21/00; A61P25/28
Domestic Patent References:
| WO2009002146A1 | 2008-12-31 | |||
| WO2005060952A1 | 2005-07-07 | |||
| WO2005067363A2 | 2005-07-28 | |||
| WO2003017945A2 | 2003-03-06 | |||
| WO2011078654A1 | 2011-06-30 |
Foreign References:
| US20040043013A1 | 2004-03-04 |
Other References:
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PLANAS M ET AL: "Micronutrient supplementation in mild Alzheimer disease patients", CLINICAL NUTRITION 200404 GB LNKD- DOI:10.1016/S0261-5614(03)00106-7, vol. 23, no. 2, April 2004 (2004-04-01), pages 265 - 272, XP055006827, ISSN: 0261-5614
WOUTERS-WESSELING W ET AL: "Study of the effect of a liquid nutrition supplement on the nutritional status of psycho-geriatric nursing home patients", EUROPEAN JOURNAL OF CLINICAL NUTRITION 2002 GB LNKD- DOI:10.1038/SJ/EJCN/1601319, vol. 56, no. 3, 2002, pages 245 - 251, XP002666057, ISSN: 0954-3007
FAXEN-IRVING G ET AL: "The effect of nutritional intervention in elderly subjects residing in group-living for the demented", EUROPEAN JOURNAL OF CLINICAL NUTRITION 2002 GB LNKD- DOI:10.1038/SJ/EJCN/1601304, vol. 56, no. 3, 2002, pages 221 - 227, XP008153446, ISSN: 0954-3007
MANDERS M ET AL: "The effect of a nutrient dense drink on mental and physical function in institutionalized elderly people", JOURNAL OF NUTRITION, HEALTH AND AGING 2009 SERDI PUBLISHING COMPANY FRA LNKD- DOI:10.1007/S12603-009-0211-X, vol. 13, no. 9, 2009, pages 760 - 767, XP055032497, ISSN: 1279-7707
LAUQUE S ET AL: "Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: A prospective randomized study", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200410 US LNKD- DOI:10.1111/J.1532-5415.2004.52464.X, vol. 52, no. 10, October 2004 (2004-10-01), pages 1702 - 1707, XP055032496, ISSN: 0002-8614
FAXEN IRVING G ET AL: "Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: The omega-3 Alzheimer's disease study", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200901 US LNKD- DOI:10.1111/J.1532-5415.2008.02055.X, vol. 57, no. 1, January 2009 (2009-01-01), pages 11 - 17, XP055032495, ISSN: 0002-8614
PLANAS M ET AL: "Micronutrient supplementation in mild Alzheimer disease patients", CLINICAL NUTRITION 200404 GB LNKD- DOI:10.1016/S0261-5614(03)00106-7, vol. 23, no. 2, April 2004 (2004-04-01), pages 265 - 272, XP055006827, ISSN: 0261-5614
WOUTERS-WESSELING W ET AL: "Study of the effect of a liquid nutrition supplement on the nutritional status of psycho-geriatric nursing home patients", EUROPEAN JOURNAL OF CLINICAL NUTRITION 2002 GB LNKD- DOI:10.1038/SJ/EJCN/1601319, vol. 56, no. 3, 2002, pages 245 - 251, XP002666057, ISSN: 0954-3007
FAXEN-IRVING G ET AL: "The effect of nutritional intervention in elderly subjects residing in group-living for the demented", EUROPEAN JOURNAL OF CLINICAL NUTRITION 2002 GB LNKD- DOI:10.1038/SJ/EJCN/1601304, vol. 56, no. 3, 2002, pages 221 - 227, XP008153446, ISSN: 0954-3007
MANDERS M ET AL: "The effect of a nutrient dense drink on mental and physical function in institutionalized elderly people", JOURNAL OF NUTRITION, HEALTH AND AGING 2009 SERDI PUBLISHING COMPANY FRA LNKD- DOI:10.1007/S12603-009-0211-X, vol. 13, no. 9, 2009, pages 760 - 767, XP055032497, ISSN: 1279-7707
LAUQUE S ET AL: "Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: A prospective randomized study", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200410 US LNKD- DOI:10.1111/J.1532-5415.2004.52464.X, vol. 52, no. 10, October 2004 (2004-10-01), pages 1702 - 1707, XP055032496, ISSN: 0002-8614
FAXEN IRVING G ET AL: "Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: The omega-3 Alzheimer's disease study", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200901 US LNKD- DOI:10.1111/J.1532-5415.2008.02055.X, vol. 57, no. 1, January 2009 (2009-01-01), pages 11 - 17, XP055032495, ISSN: 0002-8614
Attorney, Agent or Firm:
JANSEN, C.M. et al. (Johan de Wittlaan 7, JR Den Haag, NL)
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