Title:
A COMBINATION DOSAGE OF A CYCLOOXYGENASE (COX) INHIBITOR, A VITAMIN D3 INCLUDING ANALOGUES AND METABOLITES THEREOF AND/OR CALCIUM FOR PREVENTION OF EPITHELIAL CANCER
Document Type and Number:
WIPO Patent Application WO2002080889
Kind Code:
A3
Abstract:
The present invention relates to a method for prevention of epithelial cancer such as lung, bladder, prostate or gynaecological cancer or the initiation and/or progression of epithelial cancer such as lung, bladder, prostate or gynaecological cancer in a human comprising administering to the human of a combination dosage of a cyclooxygenase (COX) inhibitor, a vitamin D3 including analogues and metabolites thereof and/or calcium. In a further aspect the invention relates to a method for reducing the effective dosage of ASA in a chemopreventive treatment of epithelial cancer in a human by co-administration with a non toxic dosage of a vitamin D3 including analogues and metabolites thereof and/or Ca in the form of a combination dosage. In another embodiment the invention relates to the use of a cyclooxygenase (COX) inhibitor, a vitamin D3 including analogues and metabolites thereof and/or calcium for the preparation of a medicament for the prevention of epithelial cancer such as lung, bladder, prostate or gynaecological cancer or the initiation and/or progression of epithelial cancer such as lung, bladder, prostate or gynaecological cancer.
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Inventors:
RASKOV HANS HENRIK (DK)
Application Number:
PCT/DK2002/000231
Publication Date:
February 20, 2003
Filing Date:
April 05, 2002
Export Citation:
Assignee:
COLOTECH AS (DK)
RASKOV HANS HENRIK (DK)
RASKOV HANS HENRIK (DK)
International Classes:
A61K31/593; A61K31/616; A61K33/06; A61K45/06; A61P35/00; (IPC1-7): A61K33/06; A61K31/593; A61K31/616; A61P35/00
Domestic Patent References:
| WO2001022974A1 | 2001-04-05 |
Foreign References:
| US5948443A | 1999-09-07 |
Other References:
DUPERRON C ET AL: "Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.", CARCINOGENESIS, vol. 18, no. 5, 1997, pages 1001 - 1006, XP002902566
BADRINATH R. KONETY ET AL: "Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo.", THE JOURNAL OF UROLOGY, vol. 165, January 2001 (2001-01-01), pages 253 - 258, XP002902567
DR. O.W. BRAWLEY ET AL: "The future of prostate cancer prevention.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 952, 2001, pages 145 - 152, XP002902568
HOSOMI Y ET AL: "Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung.", LUNG CANCER, vol. 30, 2000, pages 73 - 81, XP002902569
BADRINATH R. KONETY ET AL: "Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo.", THE JOURNAL OF UROLOGY, vol. 165, January 2001 (2001-01-01), pages 253 - 258, XP002902567
DR. O.W. BRAWLEY ET AL: "The future of prostate cancer prevention.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 952, 2001, pages 145 - 152, XP002902568
HOSOMI Y ET AL: "Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung.", LUNG CANCER, vol. 30, 2000, pages 73 - 81, XP002902569
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