Title:
COMBINATION DRUG THERAPY FOR TREATING HYPERTENSION
Document Type and Number:
WIPO Patent Application WO2004087132
Kind Code:
A3
Abstract:
Disclosed are compositions and methods for treating, preventing, and ameliorating hypertension, especially in patients with coronary artery disease, patients at risk for strokes, patients with renal disease, and patients with diabetes or at risk for diabetes. The compositions and methods relate to a combination therapy using three classes of anti-hypertension drugs, including calcium antagonists, angiotensin-converting-enzyme inhibitors, and diuretics. The preferred drugs in the compositions and methods are verapamil, trandolapril, and hydrochlorothiazide.
Inventors:
PEPINE CARL J (US)
HANDBERG EILEEN M (US)
COOPER-DEHOFF RHONDA M (US)
NABULSI AZMI (US)
ALTMAN ROBERT (US)
DRAJESK JEFF (US)
WILLIAMS LAURA (US)
ZILLES PETER S (DE)
LEGLER UDO F (DE)
HANDBERG EILEEN M (US)
COOPER-DEHOFF RHONDA M (US)
NABULSI AZMI (US)
ALTMAN ROBERT (US)
DRAJESK JEFF (US)
WILLIAMS LAURA (US)
ZILLES PETER S (DE)
LEGLER UDO F (DE)
Application Number:
PCT/US2004/010052
Publication Date:
February 17, 2005
Filing Date:
April 01, 2004
Export Citation:
Assignee:
UNIV FLORIDA (US)
ABBOTT LAB (US)
PEPINE CARL J (US)
HANDBERG EILEEN M (US)
COOPER-DEHOFF RHONDA M (US)
NABULSI AZMI (US)
ALTMAN ROBERT (US)
DRAJESK JEFF (US)
WILLIAMS LAURA (US)
ZILLES PETER S (DE)
LEGLER UDO F (DE)
ABBOTT LAB (US)
PEPINE CARL J (US)
HANDBERG EILEEN M (US)
COOPER-DEHOFF RHONDA M (US)
NABULSI AZMI (US)
ALTMAN ROBERT (US)
DRAJESK JEFF (US)
WILLIAMS LAURA (US)
ZILLES PETER S (DE)
LEGLER UDO F (DE)
International Classes:
A61K31/13; A61K31/135; A61K31/277; A61K31/40; A61K31/404; A61K31/54; A61K31/549; A61K31/55; A61P9/12; (IPC1-7): A61K31/40; A61K31/13; A61K31/54; A61P9/12
Other References:
PUNZI, H. A. ET AL.: "The treatment of severe hypertension with trandolapril, verapamil and hydrochlorothiazide", JOURNAL OF HUMAN HYPERTENSION, vol. 11, 1997, pages 477 - 481, XP008035060
SKOULARIGIS, J. ET AL.: "Once-daily fixed dose combinations of verapamil and trandolapril in black patients with mild to moderate hypertension: a new choice for first line treatment", INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 35, no. 2, 1997, pages 51 - 55, XP008035055
SKOULARIGIS, J. ET AL.: "Once-daily fixed dose combinations of verapamil and trandolapril in black patients with mild to moderate hypertension: a new choice for first line treatment", INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 35, no. 2, 1997, pages 51 - 55, XP008035055
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