Title:
COMBINATION THERAPY OF DONEPEZIL AND TADALAFIL FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR COGNITIVE IMPAIRMENT
Document Type and Number:
WIPO Patent Application WO/2022/098177
Kind Code:
A1
Abstract:
The present invention relates to a combination therapy of donepezil and tadalafil for the prevention, treatment or improvement of Alzheimer's disease or cognitive impairment. The combined administration of donepezil and tadalafil according to the present invention has a superior effect on improving Alzheimer's disease or cognitive impairment as compared to single administration of donepezil, which is able to be effectively used as a therapeutic therapy or a complex agent for Alzheimer's disease or cognitive impairment.
Inventors:
LEE SUKCHAN (KR)
CHI YONG HA (KR)
RYU HYUN-HEE (KR)
JEONG MISO (KR)
CHI YONG HA (KR)
RYU HYUN-HEE (KR)
JEONG MISO (KR)
Application Number:
PCT/KR2021/016078
Publication Date:
May 12, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
NEURORIVE INC (KR)
International Classes:
A61K31/445; A23L33/10; A61K31/27; A61K31/473; A61K31/4985; A61K31/506; A61K31/519; A61K31/53; A61K31/55; A61P25/28
Domestic Patent References:
| WO2008144061A2 | 2008-11-27 |
Foreign References:
| US20090227562A1 | 2009-09-10 |
Other References:
MAO FEI, WANG HUAN, NI WEI, ZHENG XINYU, WANG MANJIONG, BAO KETING, LING DAZHENG, LI XIAOKANG, XU YIXIANG, ZHANG HAIYAN, LI JIAN: "Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease", ACS CHEMICAL NEUROSCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 2, 21 February 2018 (2018-02-21), US , pages 328 - 345, XP055927926, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00345
ZHANG PENGFEI; XU SHENGTAO; ZHU ZHEYING; XU JINYI: "Multi-target design strategies for the improved treatment of Alzheimer's disease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 176, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 228 - 247, XP085707333, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2019.05.020
NI WEI, WANG HUAN, LI XIAOKANG, ZHENG XINYU, WANG MANJIONG, ZHANG JIAN, GONG QI, LING DAZHENG, MAO FEI, ZHANG HAIYAN, LI JIAN: "Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5)", ACS CHEMICAL NEUROSCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 7, 18 July 2018 (2018-07-18), US , pages 1625 - 1636, XP055927929, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00014
ZHANG PENGFEI; XU SHENGTAO; ZHU ZHEYING; XU JINYI: "Multi-target design strategies for the improved treatment of Alzheimer's disease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 176, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 228 - 247, XP085707333, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2019.05.020
NI WEI, WANG HUAN, LI XIAOKANG, ZHENG XINYU, WANG MANJIONG, ZHANG JIAN, GONG QI, LING DAZHENG, MAO FEI, ZHANG HAIYAN, LI JIAN: "Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5)", ACS CHEMICAL NEUROSCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 7, 18 July 2018 (2018-07-18), US , pages 1625 - 1636, XP055927929, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00014
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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