Title:
COMBINATION OF A TNF-ALPHA ANTAGONIST AND A VEGF ANTAGONIST FOR USE IN THE TREATMENT OR PREVENTION OF DISEASES OF THE EYE.
Document Type and Number:
WIPO Patent Application WO/2010/136492
Kind Code:
A3
Abstract:
Combinations of TNF&alpha,- antagonists with VEGF antagonists for use in treating diseases of the eye, and provides antigen-binding proteins which bind to TNFα or a TNFα receptor and/or VEGF or a VEGF receptor.
Inventors:
ADAMSON PETER (GB)
ERTL PETER FRANZ (GB)
GERMASCHEWSKI VOLKER (GB)
GOUGH GERALD WAYNE (GB)
STEWARD MICHAEL (GB)
ERTL PETER FRANZ (GB)
GERMASCHEWSKI VOLKER (GB)
GOUGH GERALD WAYNE (GB)
STEWARD MICHAEL (GB)
Application Number:
PCT/EP2010/057246
Publication Date:
February 24, 2011
Filing Date:
May 26, 2010
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
ADAMSON PETER (GB)
ERTL PETER FRANZ (GB)
GERMASCHEWSKI VOLKER (GB)
GOUGH GERALD WAYNE (GB)
STEWARD MICHAEL (GB)
ADAMSON PETER (GB)
ERTL PETER FRANZ (GB)
GERMASCHEWSKI VOLKER (GB)
GOUGH GERALD WAYNE (GB)
STEWARD MICHAEL (GB)
International Classes:
A61K39/395; A61P27/02; C07K16/22; C07K16/24; C07K14/715
Domestic Patent References:
| WO2006003388A2 | 2006-01-12 | |||
| WO2009068649A2 | 2009-06-04 |
Foreign References:
| US20040091455A1 | 2004-05-13 |
Other References:
A. ADAMIS ET AL.: "Immunological mechanisms in the pathogenesis of diabetic retinopathy.", SEMINARS IN IMMUNOPATHOLOGY, vol. 30, no. 2, 14 March 2008 (2008-03-14), Germany, pages 65 - 84, XP019625605
L. MAINES ET AL.: "Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: Implications for angiogenic ocular diseases.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 47, no. 11, November 2006 (2006-11-01), USA, pages 5022 - 5031, XP002592513
A. ROTHOVA: "Inflammatory cystoid macular edema.", CURRENT OPINION IN OPHTHALMOLOGY, vol. 18, no. 6, November 2007 (2007-11-01), USA, pages 487 - 492, XP008124386
E. RODRIGUES ET AL.: "Therapeutic monoclonal antibodies in ophthalmology.", PROGRESS IN RETINAL AND EYE RESEARCH, vol. 28, no. 2, March 2009 (2009-03-01), England, pages 117 - 144, XP025948069
L. HOLT ET AL.: "Domain antibodies: proteins for therapy.", TRENDS IN BIOTECHNOLOGY, vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 490, XP004467495
L. MAINES ET AL.: "Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: Implications for angiogenic ocular diseases.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 47, no. 11, November 2006 (2006-11-01), USA, pages 5022 - 5031, XP002592513
A. ROTHOVA: "Inflammatory cystoid macular edema.", CURRENT OPINION IN OPHTHALMOLOGY, vol. 18, no. 6, November 2007 (2007-11-01), USA, pages 487 - 492, XP008124386
E. RODRIGUES ET AL.: "Therapeutic monoclonal antibodies in ophthalmology.", PROGRESS IN RETINAL AND EYE RESEARCH, vol. 28, no. 2, March 2009 (2009-03-01), England, pages 117 - 144, XP025948069
L. HOLT ET AL.: "Domain antibodies: proteins for therapy.", TRENDS IN BIOTECHNOLOGY, vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 490, XP004467495
Attorney, Agent or Firm:
REDDISH, Anna et al. (Global Patents CN925.1980 Great West Road, Brentford Middlesex TW8 9GS, GB)
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