Title:
COMBINATION USE OF INHIBITOR TARGETING PD-1/PD-L1 AND COX-2 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/017420
Kind Code:
A1
Abstract:
Provided are: a new therapeutic strategy by using an inhibitor that targets PD-1/PD-L1; a pharmaceutical composition which contains a COX-2 inhibitor and is administered at any period of time prior to, subsequent to, or at the same time of the administering of the inhibitor targeting PD-1/PD-L1; and an immunostimulating effect enhancer which is for the inhibitor targeting PD-1/PD-L1 and contains a COX-2 inhibitor.
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Inventors:
KONNAI SATORU (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
OKAGAWA TOMOHIRO (JP)
MAEKAWA NAOYA (JP)
NISHIMORI ASAMI (JP)
GOTO SHINYA (JP)
SUZUKI YASUHIKO (JP)
NAKAJIMA CHIE (JP)
SAJIKI YAMATO (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
OKAGAWA TOMOHIRO (JP)
MAEKAWA NAOYA (JP)
NISHIMORI ASAMI (JP)
GOTO SHINYA (JP)
SUZUKI YASUHIKO (JP)
NAKAJIMA CHIE (JP)
SAJIKI YAMATO (JP)
Application Number:
PCT/JP2018/027041
Publication Date:
January 24, 2019
Filing Date:
July 19, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
FUSO PHARMACEUTICAL IND (JP)
FUSO PHARMACEUTICAL IND (JP)
International Classes:
A61K45/06; A61K31/196; A61K31/341; A61K31/403; A61K31/407; A61K31/5415; A61K31/63; A61K39/395; A61P31/00; A61P35/00; A61P43/00; C07K16/28
Domestic Patent References:
| WO2018049015A1 | 2018-03-15 | |||
| WO2018034225A1 | 2018-02-22 |
Foreign References:
| US20170111815A1 | 2017-04-20 | |||
| JP2017140891A | 2017-08-17 | |||
| JP2018016074A | 2018-02-01 | |||
| JP2017061389A | 2017-03-30 | |||
| JP2016159089A | 2016-08-15 |
Other References:
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LI, Y. ET AL.: "Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.", ONCOIMMUNOLOGY, vol. 5, no. 2, e1074374, pages 1 - 12, XP055497547, ISSN: 2162-4011, DOI: 10.1080/2162402X.2015.1074374
ASANO, YUMIKO ET AL.: "DIO-17: Review on method for controlling tumor disease of dog with respect to usage of combination of COX-2 inhibitors and anti-PD-L1 antibodies", NIPPON JUI GAKKAI GAKUJUTSU SHUKAI KOEN YOSHISHU = PROCEEDINGS OF THE JAPANESE SOCIETY OF VETERINARY; LECTURE ABSTRACTS OF 160TH ACADEMIC CONFERENCE OF THE JAPANESE SOCIETY OF VETERINARY SCIENCE, vol. 160, August 2017 (2017-08-01), JAPAN, pages 371, XP009519158, ISSN: 1347-8621
CHALABI, M. ET AL.: "Nivolumab, ipilimumab and COX2-inhibition in early stage colon cancer", ANNALS OF ONCOLOGY, vol. 28, no. suppl. 5, 9 September 2017 (2017-09-09), pages 611Tip, XP055672554, ISSN: 1569-8041
BRAMER JRECKAMP K ET AL.: "Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer", N ENGL J MED, vol. 373, 2015, pages 1627 - 1639, XP055667804, DOI: 10.1056/NEJMoa1507643
HAMANISHI JMANDAI MIKEDA T ET AL.: "Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients with Platinum-Resistant Ovarian Cancer", J CLIN ONCOL, vol. 33, 2015, pages 4015 - 4022, XP055625077, DOI: 10.1200/JCO.2015.62.3397
MOTZER RJESCUDIER BMCDERMOTT DF ET AL.: "Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma", N ENGL J MED, vol. 373, 2015, pages 1803 - 1813, XP055667810, DOI: 10.1056/NEJMoa1510665
BARBER DLWHERRY EJMASOPUST D ET AL.: "Restoring function in exhausted CD8 T cells during chronic viral infection", NATURE, vol. 439, 2006, pages 682 - 687, XP055198624, DOI: 10.1038/nature04444
VELU VTITANJI KZHU B ET AL.: "Enhancing SIV-specific immunity in vivo by PD-1 blockade", NATURE, vol. 458, 2009, pages 206 - 210
"GenBank", Database accession no. AF354267.1
OHASHI EINOUE KKAGECHIKA HHONG SHNAKAGAWA T ET AL.: "Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines", J VET MED SCI, vol. 64, 2002, pages 169 - 172
OHASHI EHONG SHTAKAHASHI TNAKAGAWA TMOCHIZUKI M ET AL.: "Effect of retinoids on growth inhibition of two canine melanoma cell lines", J VET MED SCI, vol. 63, 2001, pages 83 - 86
BARROGA EFKADOSAWA TOKUMURA MFUJINAGA T: "Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice", J VET MED SCI, vol. 61, 1999, pages 361 - 367
IKEBUCHI RKONNAI SSHIRAI TSUNDEN YMURATA SONUMA MOHASHI K, VET RES., vol. 42, 26 September 2011 (2011-09-26), pages 103
IKEBUCHI RKONNAI SOKAGAWA TYOKOYAMA KNAKAJIMA CSUZUKI YMURATA SOHASHI K, IMMUNOLOGY, vol. 142, no. 4, August 2014 (2014-08-01), pages 551 - 561
MAEKAWA NKONNAI SIKEBUCHI ROKAGAWA TADACHI MTAKAGI SKAGAWA YNAKAJIMA CSUZUKI YMURATA S, PLOS ONE, vol. 9, no. 6, 10 June 2014 (2014-06-10), pages e98415
OKAGAWA TKONNAI SNISHIMORI AIKEBUCHI RMIZOROGI SNAGATA RKAWAJI STANAKA SKAGAWA YMURATA S, INFECT IMMUN, vol. 84, 2016, pages 77 - 89
PYEON DDIAZ FJSPLITTER GA, J VIROL., vol. 74, 2000, pages 5740 - 5745
WARIS DSIDDIQUI A, J VIROL., vol. 79, 2005, pages 9725 - 9734
IKEBUCHI RKONNAI SSUNDEN YONUMA MOHASHI K, MICROBIOL. IMMUNOL., vol. 54, no. 5, May 2010 (2010-05-01), pages 291 - 298
IKEBUCHI RKONNAI SSHIRAI TSUNDEN YMURATA SONUMA MOHASHI K, VET. RES., vol. 42, 26 September 2011 (2011-09-26), pages 103
IKEBUCHI RKONNAI SOKAGAWA TYOKOYAMA KNAKAJIMA CSUZUKI YMURATA SOHASHI K, VET. RES., vol. 44, 22 July 2013 (2013-07-22), pages 59
See also references of EP 3656400A4
LI, Y. ET AL.: "Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.", ONCOIMMUNOLOGY, vol. 5, no. 2, e1074374, pages 1 - 12, XP055497547, ISSN: 2162-4011, DOI: 10.1080/2162402X.2015.1074374
ASANO, YUMIKO ET AL.: "DIO-17: Review on method for controlling tumor disease of dog with respect to usage of combination of COX-2 inhibitors and anti-PD-L1 antibodies", NIPPON JUI GAKKAI GAKUJUTSU SHUKAI KOEN YOSHISHU = PROCEEDINGS OF THE JAPANESE SOCIETY OF VETERINARY; LECTURE ABSTRACTS OF 160TH ACADEMIC CONFERENCE OF THE JAPANESE SOCIETY OF VETERINARY SCIENCE, vol. 160, August 2017 (2017-08-01), JAPAN, pages 371, XP009519158, ISSN: 1347-8621
CHALABI, M. ET AL.: "Nivolumab, ipilimumab and COX2-inhibition in early stage colon cancer", ANNALS OF ONCOLOGY, vol. 28, no. suppl. 5, 9 September 2017 (2017-09-09), pages 611Tip, XP055672554, ISSN: 1569-8041
BRAMER JRECKAMP K ET AL.: "Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer", N ENGL J MED, vol. 373, 2015, pages 1627 - 1639, XP055667804, DOI: 10.1056/NEJMoa1507643
HAMANISHI JMANDAI MIKEDA T ET AL.: "Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients with Platinum-Resistant Ovarian Cancer", J CLIN ONCOL, vol. 33, 2015, pages 4015 - 4022, XP055625077, DOI: 10.1200/JCO.2015.62.3397
MOTZER RJESCUDIER BMCDERMOTT DF ET AL.: "Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma", N ENGL J MED, vol. 373, 2015, pages 1803 - 1813, XP055667810, DOI: 10.1056/NEJMoa1510665
BARBER DLWHERRY EJMASOPUST D ET AL.: "Restoring function in exhausted CD8 T cells during chronic viral infection", NATURE, vol. 439, 2006, pages 682 - 687, XP055198624, DOI: 10.1038/nature04444
VELU VTITANJI KZHU B ET AL.: "Enhancing SIV-specific immunity in vivo by PD-1 blockade", NATURE, vol. 458, 2009, pages 206 - 210
"GenBank", Database accession no. AF354267.1
OHASHI EINOUE KKAGECHIKA HHONG SHNAKAGAWA T ET AL.: "Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines", J VET MED SCI, vol. 64, 2002, pages 169 - 172
OHASHI EHONG SHTAKAHASHI TNAKAGAWA TMOCHIZUKI M ET AL.: "Effect of retinoids on growth inhibition of two canine melanoma cell lines", J VET MED SCI, vol. 63, 2001, pages 83 - 86
BARROGA EFKADOSAWA TOKUMURA MFUJINAGA T: "Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice", J VET MED SCI, vol. 61, 1999, pages 361 - 367
IKEBUCHI RKONNAI SSHIRAI TSUNDEN YMURATA SONUMA MOHASHI K, VET RES., vol. 42, 26 September 2011 (2011-09-26), pages 103
IKEBUCHI RKONNAI SOKAGAWA TYOKOYAMA KNAKAJIMA CSUZUKI YMURATA SOHASHI K, IMMUNOLOGY, vol. 142, no. 4, August 2014 (2014-08-01), pages 551 - 561
MAEKAWA NKONNAI SIKEBUCHI ROKAGAWA TADACHI MTAKAGI SKAGAWA YNAKAJIMA CSUZUKI YMURATA S, PLOS ONE, vol. 9, no. 6, 10 June 2014 (2014-06-10), pages e98415
OKAGAWA TKONNAI SNISHIMORI AIKEBUCHI RMIZOROGI SNAGATA RKAWAJI STANAKA SKAGAWA YMURATA S, INFECT IMMUN, vol. 84, 2016, pages 77 - 89
PYEON DDIAZ FJSPLITTER GA, J VIROL., vol. 74, 2000, pages 5740 - 5745
WARIS DSIDDIQUI A, J VIROL., vol. 79, 2005, pages 9725 - 9734
IKEBUCHI RKONNAI SSUNDEN YONUMA MOHASHI K, MICROBIOL. IMMUNOL., vol. 54, no. 5, May 2010 (2010-05-01), pages 291 - 298
IKEBUCHI RKONNAI SSHIRAI TSUNDEN YMURATA SONUMA MOHASHI K, VET. RES., vol. 42, 26 September 2011 (2011-09-26), pages 103
IKEBUCHI RKONNAI SOKAGAWA TYOKOYAMA KNAKAJIMA CSUZUKI YMURATA SOHASHI K, VET. RES., vol. 44, 22 July 2013 (2013-07-22), pages 59
See also references of EP 3656400A4
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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