Title:
COMBINATION USE OF NOVEL LACTOBACILLUS PLANTARUM STRAIN AND STRAIN-DERIVED POLYSACCHARIDE FOR PREVENTING OR TREATING TUMORS
Document Type and Number:
WIPO Patent Application WO/2023/282675
Kind Code:
A1
Abstract:
The present invention relates to a combination use of a novel Lactobacillus plantarum IMB19 strain and/or polysaccharides derived from the strain with an anticancer drug for preventing or treating tumors. The novel Lactobacillus plantarum IMB19 strain and polysaccharides derived from the strain of the present invention exhibit an excellent ability to stimulate CD8+T cell activity and exhibit excellent Treg cell inhibitory activity, and stimulate and improve antitumor immune response through various mechanisms such as increased macrophage infiltration in CPS tumors and differentiation and reprogramming of macrophages into an inflammatory phenotype (M1). Furthermore, the strain and the polysaccharides may significantly increase antitumor immune response when administered in combination with an anticancer drug, particularly an immuno-anticancer drug such as a PD-1 or PD-L1 inhibitor (e.g., a PD-1 antibody, a PD-L1 antibody, or the like), and exhibit a remarkable tumor growth suppression effect compared to the case of using the anticancer drug alone. Therefore, the present invention can be effectively used to prevent, relieve, or treat tumors through administration in combination with various anticancer drugs.
Inventors:
IM SIN-HYEOG (KR)
SHARMA GARIMA (KR)
SHARMA AMIT KUMAR (KR)
PARK SUNHEE (KR)
SHARMA GARIMA (KR)
SHARMA AMIT KUMAR (KR)
PARK SUNHEE (KR)
Application Number:
PCT/KR2022/009884
Publication Date:
January 12, 2023
Filing Date:
July 07, 2022
Export Citation:
Assignee:
IMMUNOBIOME INC (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
International Classes:
A61K35/747; A61K31/715; A61K45/06; A61P35/00
Foreign References:
| KR20210003432A | 2021-01-12 | |||
| KR20210003433A | 2021-01-12 |
Other References:
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TAKANO TOMOHIRO, RYUNOSUKE ENDO, YIMEI WANG, HARUYO NAKAJIMA-ADACHI, SATOSHI HACHIMURA: "Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells", BIOSCIENCE OF MICROBIOTA, FOOD AND HEALTH, 29 November 2019 (2019-11-29), pages 1 - 30, XP055827624, DOI: 10.12938/bmfh.19-019
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WHEELER MLLIMON JJUNDERHILL DM: "Immunity to Commensal Fungi: Detente and Disease", ANNU REV PATHOL, vol. 12, 2017, pages 359 - 85
ILIEV IDLEONARDI I, NAT REV IMMUNOL, vol. 17, no. 10, 2017, pages 635 - 46
UNDERHILL DMILIEV ID, NAT REV IMMUNOL, vol. 14, no. 6, 2014, pages 405 - 16
BRUBAKER SWBONHAM KSZANONI I ET AL., ANNU REV IMMUNOL, vol. 33, 2015, pages 257 - 90
NAT REV GASTROENTEROL HEPATO, vol. 11, 2014, pages 506 - 514
CRIT REV FOOD SCI NUTR, vol. 34, 1994, pages 175 - 203
FOOD SCI BIOTECHNOL, vol. 19, 2010, pages 641 - 646
INT J FOOD MICROBIOL, vol. 102, 2005, pages 143 - 150
SCIENCE, vol. 330, 2010, pages 1768 - 1773
CELL, vol. 148, 2012, pages 1258 - 1270
CANCER IMMUNOL IMMUNOTHER, vol. 55, 2006, pages 1470 - 1479
SCIENCE, vol. 342, 2013, pages 971 - 976
SCIENCE, vol. 350, 2015, pages 1079 - 1084
SCIENCE, vol. 359, 2018, pages 91 - 97
NATURE, vol. 453, 2008, pages 620 - 625
"Accession", Database accession no. KCTC 14337BP
L. LACHMAN ET AL., THE THEORY AND PRACTICE OF INDUSTRIAL PHARMACY, 1986, pages 365 - 373
H. SUCKER ET AL.: "Pharmazeutische Technologie", THIEME, 1991, pages 355 - 359
"Hagers Handbuch der pharmazeutischen Praxis", vol. 7, 1971, SPRINGER VERLAG, pages: 739 - 742
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., pages: 1689 - 1691
DELA CRU ET AL., ASM SCIENCE RECOMMENDATION, 2012
PCR, APPL ENVIRON MICROBIOL, vol. 67, 2001, pages 3450 - 3454
J CLIN MICROBIOL, vol. 52, 2014, pages 1501 - 1510
SCI IMMUNOL, 2018, pages 3
EUR J IMMUNOL, vol. 40, 2010, pages 1830 - 1835
YOON, SANG-KUN; BAE, HYOUNG-SUK; KIM, GYUNG-TAE; BAEK, YOUNG-JIN: "Augmentation of antitumor activity of antitumor drugs in combination with Lactobacillus casei HY2782", SANNEB MISAINMURHAG HOIJI - KOREAN JOURNAL OF APPLIEDMICROBIOLOGY AND BIOENGINEERING., SEOUL., KR, vol. 24, no. 1, 1 January 1996 (1996-01-01), KR , pages 37 - 43, XP009542754, ISSN: 0257-2389
DRAGICA JORGOVANOVIC;MENGJIA SONG;LIPING WANG;YI ZHANG: "Roles of IFN-γ in tumor progression and regression: a review", BIOMARKER RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 8, no. 1, 29 September 2020 (2020-09-29), London, UK , pages 1 - 16, XP021282369, DOI: 10.1186/s40364-020-00228-x
KASSAYOVÁ MONIKA, NIKITA BOBROV, LADISLAV STROJNÝ, PETER ORENDÁŠ, VLASTA DEMEČKOVÁ, RASTISLAV JENDŽELOVSKÝ, PETER KUBATKA, TERÉZIA: "Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer", ANTICANCER RESEARCH, vol. 36, no. 6, 1 June 2016 (2016-06-01), pages 2719 - 2728, XP055955214
DANIELA M REMUS;RICHARD VAN KRANENBURG;IRIS I VAN SWAM;NICO TAVERNE;ROGER S BONGERS;MICHIEL WELS;JERRY M WELLS;PETER A BRON;MICHIE: "Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling", MICROBIAL CELL FACTORIES, SPRINGER, vol. 11, no. 1, 21 November 2012 (2012-11-21), pages 1 - 10, XP021136140, ISSN: 1475-2859, DOI: 10.1186/1475-2859-11-149
TAKANO TOMOHIRO, RYUNOSUKE ENDO, YIMEI WANG, HARUYO NAKAJIMA-ADACHI, SATOSHI HACHIMURA: "Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells", BIOSCIENCE OF MICROBIOTA, FOOD AND HEALTH, 29 November 2019 (2019-11-29), pages 1 - 30, XP055827624, DOI: 10.12938/bmfh.19-019
KAŹMIERCZAK-SIEDLECKA KAROLINA, ROVIELLO GIANDOMENICO, CATALANO MARTINA, POLOM KAROL: "Gut Microbiota Modulation in the Context of Immune-Related Aspects of Lactobacillus spp. and Bifidobacterium spp. in Gastrointestinal Cancers", NUTRIENTS, vol. 13, no. 8, 1 January 2021 (2021-01-01), pages 2674, XP093022567, DOI: 10.3390/nu13082674
CERF-BENSUSSAN NGABORIAU-ROUTHIAU V: "The immune system and the gut microbiota: friends or foes", NAT REV IMMUNOL, vol. 10, no. 10, 2010, pages 735 - 44
WHEELER MLLIMON JJUNDERHILL DM: "Immunity to Commensal Fungi: Detente and Disease", ANNU REV PATHOL, vol. 12, 2017, pages 359 - 85
ILIEV IDLEONARDI I, NAT REV IMMUNOL, vol. 17, no. 10, 2017, pages 635 - 46
UNDERHILL DMILIEV ID, NAT REV IMMUNOL, vol. 14, no. 6, 2014, pages 405 - 16
BRUBAKER SWBONHAM KSZANONI I ET AL., ANNU REV IMMUNOL, vol. 33, 2015, pages 257 - 90
NAT REV GASTROENTEROL HEPATO, vol. 11, 2014, pages 506 - 514
CRIT REV FOOD SCI NUTR, vol. 34, 1994, pages 175 - 203
FOOD SCI BIOTECHNOL, vol. 19, 2010, pages 641 - 646
INT J FOOD MICROBIOL, vol. 102, 2005, pages 143 - 150
SCIENCE, vol. 330, 2010, pages 1768 - 1773
CELL, vol. 148, 2012, pages 1258 - 1270
CANCER IMMUNOL IMMUNOTHER, vol. 55, 2006, pages 1470 - 1479
SCIENCE, vol. 342, 2013, pages 971 - 976
SCIENCE, vol. 350, 2015, pages 1079 - 1084
SCIENCE, vol. 359, 2018, pages 91 - 97
NATURE, vol. 453, 2008, pages 620 - 625
"Accession", Database accession no. KCTC 14337BP
L. LACHMAN ET AL., THE THEORY AND PRACTICE OF INDUSTRIAL PHARMACY, 1986, pages 365 - 373
H. SUCKER ET AL.: "Pharmazeutische Technologie", THIEME, 1991, pages 355 - 359
"Hagers Handbuch der pharmazeutischen Praxis", vol. 7, 1971, SPRINGER VERLAG, pages: 739 - 742
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., pages: 1689 - 1691
DELA CRU ET AL., ASM SCIENCE RECOMMENDATION, 2012
PCR, APPL ENVIRON MICROBIOL, vol. 67, 2001, pages 3450 - 3454
J CLIN MICROBIOL, vol. 52, 2014, pages 1501 - 1510
SCI IMMUNOL, 2018, pages 3
EUR J IMMUNOL, vol. 40, 2010, pages 1830 - 1835
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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