Title:
COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO2005027973
Kind Code:
A3
Abstract:
The invention relates to a combination therapy for treating patients suffering from diseases characterized by cell proliferation and infiltration of inflammatory cells, coronary diseases, hypertension, renal diseases, diabetes, or ocular diseases and conditions. The patient is treated with a combination of: (a) a VEGF inhibitor compound; and (b) one or more second therapeutic agents selected from the group consisting of: i. angiostatic steroids; ii. photosensitizers; iii. implants containing corticosteroids; iv. AT1 receptor antagonists; V. ACE inhibitors; vi. cyclooxygenase inhibitors; vii. IGF-IR inhibitors; viii. mTOR kinase inhibitors; ix. somatostatin receptor antagonists; X. P13K inhibitors; A. Raf kinase inhibitors; xii. PKC inhibitors; xiii. integrin antagonists; xiv. endogenous anti-anglogenic molecules; and xv. PEDF and analogs.
Inventors:
BOLD GUIDO (CH)
BRUEGGEN JOSEF BERNHARD (CH)
HUANG JERRY MIN-JIAN (US)
KINDER FREDERICK RAY (US)
LANE HEIDI (CH)
LATOUR ELISABETH JEANNE (FR)
MANLEY PAUL WILLIAM (CH)
WOOD JEANETTE MARJORIE (CH)
BRUEGGEN JOSEF BERNHARD (CH)
HUANG JERRY MIN-JIAN (US)
KINDER FREDERICK RAY (US)
LANE HEIDI (CH)
LATOUR ELISABETH JEANNE (FR)
MANLEY PAUL WILLIAM (CH)
WOOD JEANETTE MARJORIE (CH)
Application Number:
PCT/EP2004/010701
Publication Date:
September 09, 2005
Filing Date:
September 23, 2004
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
BOLD GUIDO (CH)
BRUEGGEN JOSEF BERNHARD (CH)
HUANG JERRY MIN-JIAN (US)
KINDER FREDERICK RAY (US)
LANE HEIDI (CH)
LATOUR ELISABETH JEANNE (FR)
MANLEY PAUL WILLIAM (CH)
WOOD JEANETTE MARJORIE (CH)
NOVARTIS PHARMA GMBH (AT)
BOLD GUIDO (CH)
BRUEGGEN JOSEF BERNHARD (CH)
HUANG JERRY MIN-JIAN (US)
KINDER FREDERICK RAY (US)
LANE HEIDI (CH)
LATOUR ELISABETH JEANNE (FR)
MANLEY PAUL WILLIAM (CH)
WOOD JEANETTE MARJORIE (CH)
International Classes:
A61K45/06; A61P3/00; A61P9/00; A61P27/00; A61P35/00; (IPC1-7): A61K45/06; A61P3/00; A61P9/00; A61P27/00; A61P35/00
Domestic Patent References:
| WO2001055114A1 | 2001-08-02 | |||
| WO2002066470A1 | 2002-08-29 | |||
| WO2002068406A2 | 2002-09-06 | |||
| WO2003015778A1 | 2003-02-27 | |||
| WO2002102783A1 | 2002-12-27 | |||
| WO2003035047A2 | 2003-05-01 | |||
| WO1998031359A1 | 1998-07-23 |
Foreign References:
| US20010047007A1 | 2001-11-29 |
Other References:
GOODMAN G A ET AL GOODMAN GILMAN A: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , ADRENOCORTICAL STEROIDS", PHARMACOLOGICAL BASIS OF THERAPEUTICS, GOODMAN GILMAN'S PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK, MACMILLAN PUBL. CIE, US, vol. ED. 7, 1985, pages 1655 - 1676, XP002235123
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