Title:
COMBINED PREPARATIONS COMPRISING DAUNORUBICIN DERIVATIVES AND HER2 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2001005425
Kind Code:
A3
Abstract:
There are provided the combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'-methansulfonyl daunorubicin and a recombinant humanized anti-HER2 antibody, preferably trastuzumab, in the treatment of tumors and the use of said combination in the treatment and/or prevention of tumor metastasis.
Inventors:
GERONI CRISTINA (IT)
RIPAMONTI MARINA (IT)
CARUSO MICHELE (IT)
SUARATO ANTONINO (IT)
RIPAMONTI MARINA (IT)
CARUSO MICHELE (IT)
SUARATO ANTONINO (IT)
Application Number:
PCT/EP2000/006540
Publication Date:
May 17, 2001
Filing Date:
July 10, 2000
Export Citation:
Assignee:
PHARMACIA & UPJOHN SPA (IT)
GERONI CRISTINA (IT)
RIPAMONTI MARINA (IT)
CARUSO MICHELE (IT)
SUARATO ANTONINO (IT)
GERONI CRISTINA (IT)
RIPAMONTI MARINA (IT)
CARUSO MICHELE (IT)
SUARATO ANTONINO (IT)
International Classes:
A61K31/704; A61K39/395; A61P35/00; C07K16/32; (IPC1-7): A61K31/70; A61K39/395; A61P35/00
Domestic Patent References:
| WO2000069460A1 | 2000-11-23 | |||
| WO1999031140A1 | 1999-06-24 | |||
| WO2000044225A1 | 2000-08-03 | |||
| WO2000061185A1 | 2000-10-19 | |||
| WO1989006692A1 | 1989-07-27 |
Foreign References:
| US5677171A | 1997-10-14 | |||
| US5705157A | 1998-01-06 | |||
| EP0328147A2 | 1989-08-16 |
Other References:
BASELGA J ET AL: "HER2 Overexpression and Paclitaxel sensitivity in breast cancer: Therapeutic implications", ONCOLOGY,CH,S. KARGER AG, BASEL, vol. 11, no. 3, SUPPL. 02, March 1997 (1997-03-01), pages 43 - 48, XP002100077, ISSN: 0030-2414
Download PDF: