Title:
COMBINED TREATMENT OF MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2010/092485
Kind Code:
A3
Abstract:
The invention concerns a novel treatment multiple sclerosis, based on induced anaemia, followed by administration of an erythropoiesis-stimulating agent (ESA). In a preferred embodiment, the ESA is darbopoietin alpha, CERA or Hematide. The anaemia is induced by successive bloodlettings or by administration of an iron chelator, such as deferiprone, deferoxamine, polyanionic amines, substituted polyaza compounds, desferrithiocon, hydroxybenzyl-ethylenediamine-diacetic acid and pyridoxal isonicotinoyl hydra z one.
Inventors:
CREANGE ALAIN (FR)
GALACTEROS FREDERIC (FR)
LEFAUCHEUR JEAN-PASCAL (FR)
GALACTEROS FREDERIC (FR)
LEFAUCHEUR JEAN-PASCAL (FR)
Application Number:
PCT/IB2010/000426
Publication Date:
November 25, 2010
Filing Date:
February 12, 2010
Export Citation:
Assignee:
ASSIST PUBL HOPITAUX DE PARIS (FR)
CREANGE ALAIN (FR)
GALACTEROS FREDERIC (FR)
LEFAUCHEUR JEAN-PASCAL (FR)
CREANGE ALAIN (FR)
GALACTEROS FREDERIC (FR)
LEFAUCHEUR JEAN-PASCAL (FR)
International Classes:
A61K38/18; A61K31/4412; A61P25/28; A61P39/04
Domestic Patent References:
| WO2009010107A1 | 2009-01-22 |
Foreign References:
| DE102006004008A1 | 2007-08-02 |
Other References:
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; October 1996 (1996-10-01), KALINOWSKI M ET AL: "[Effect of deferoxamine on erythropoiesis in patients hemodialyzed for chronic renal insufficiency treated with erythropoietin]", XP002580644, Database accession no. NLM9156931
VAN DER KOOIJ M A ET AL: "Combination of deferoxamine and erythropoietin: Therapy for hypoxia-ischemia-induced brain injury in the neonatal rat?", NEUROSCIENCE LETTERS, LIMERICK, IE LNKD- DOI:10.1016/J.NEULET.2008.12.013, vol. 451, no. 2, 20 February 2009 (2009-02-20), pages 109 - 113, XP025922026, ISSN: 0304-3940, [retrieved on 20081216]
EHRENREICH HANNELORE ET AL: "Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis", BRAIN, vol. 130, no. Part 10, October 2007 (2007-10-01), pages 2577 - 2588, XP002549284, ISSN: 0006-8950
LYNCH S G ET AL: "Desferrioxamine in chronic progressive multiple sclerosis: a pilot study.", MULTIPLE SCLEROSIS (HOUNDMILLS, BASINGSTOKE, ENGLAND) OCT 1996, vol. 2, no. 3, October 1996 (1996-10-01), pages 157 - 160, XP009123849, ISSN: 1352-4585
LYNCH S G ET AL: "A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis", CELLULAR AND MOLECULAR BIOLOGY, CMB ASSOCIATIONS, NOISY-LE-GRAND, FR, vol. 46, no. 4, 1 June 2000 (2000-06-01), pages 865 - 869, XP009123850, ISSN: 0145-5680
MITCHELL K M ET AL: "Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis.", MULTIPLE SCLEROSIS (HOUNDMILLS, BASINGSTOKE, ENGLAND) NOV 2007 LNKD- PUBMED:17967839, vol. 13, no. 9, November 2007 (2007-11-01), pages 1118 - 1126, XP002580645, ISSN: 1352-4585
COMPSTON A ET AL: "Multiple sclerosis", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 372, no. 9648, 25 October 2008 (2008-10-25), pages 1502 - 1517, XP025584419, ISSN: 0140-6736, [retrieved on 20081023]
VAN DER KOOIJ M A ET AL: "Combination of deferoxamine and erythropoietin: Therapy for hypoxia-ischemia-induced brain injury in the neonatal rat?", NEUROSCIENCE LETTERS, LIMERICK, IE LNKD- DOI:10.1016/J.NEULET.2008.12.013, vol. 451, no. 2, 20 February 2009 (2009-02-20), pages 109 - 113, XP025922026, ISSN: 0304-3940, [retrieved on 20081216]
EHRENREICH HANNELORE ET AL: "Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis", BRAIN, vol. 130, no. Part 10, October 2007 (2007-10-01), pages 2577 - 2588, XP002549284, ISSN: 0006-8950
LYNCH S G ET AL: "Desferrioxamine in chronic progressive multiple sclerosis: a pilot study.", MULTIPLE SCLEROSIS (HOUNDMILLS, BASINGSTOKE, ENGLAND) OCT 1996, vol. 2, no. 3, October 1996 (1996-10-01), pages 157 - 160, XP009123849, ISSN: 1352-4585
LYNCH S G ET AL: "A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis", CELLULAR AND MOLECULAR BIOLOGY, CMB ASSOCIATIONS, NOISY-LE-GRAND, FR, vol. 46, no. 4, 1 June 2000 (2000-06-01), pages 865 - 869, XP009123850, ISSN: 0145-5680
MITCHELL K M ET AL: "Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis.", MULTIPLE SCLEROSIS (HOUNDMILLS, BASINGSTOKE, ENGLAND) NOV 2007 LNKD- PUBMED:17967839, vol. 13, no. 9, November 2007 (2007-11-01), pages 1118 - 1126, XP002580645, ISSN: 1352-4585
COMPSTON A ET AL: "Multiple sclerosis", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 372, no. 9648, 25 October 2008 (2008-10-25), pages 1502 - 1517, XP025584419, ISSN: 0140-6736, [retrieved on 20081023]
Attorney, Agent or Firm:
MARCADÉ, Véronique et al. (36 rue de St Pétersbourg, Paris, FR)
Download PDF: