Title:
COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5
Document Type and Number:
WIPO Patent Application WO/2021/237038
Kind Code:
A8
Abstract:
Arylsulfonamides of 4-heteroaryl-piperidines, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatric disorders such as substance-related misuse, substance-related disorder relapse, anxiety, depression, and psychosis.
Inventors:
LINDSLEY CRAIG W (US)
JONES CARRIE K (US)
CONN P JEFFREY (US)
HAN CHANGHO (US)
FELTS ANDREW S (US)
ORSI DOUGLAS L (US)
ENGERS JULIE L (US)
LI JINMING (US)
CAPSTICK RORY A (US)
WHOMBLE DAVID L (US)
TEMPLE KAYLA J (US)
JONES CARRIE K (US)
CONN P JEFFREY (US)
HAN CHANGHO (US)
FELTS ANDREW S (US)
ORSI DOUGLAS L (US)
ENGERS JULIE L (US)
LI JINMING (US)
CAPSTICK RORY A (US)
WHOMBLE DAVID L (US)
TEMPLE KAYLA J (US)
Application Number:
PCT/US2021/033574
Publication Date:
June 02, 2022
Filing Date:
May 21, 2021
Export Citation:
Assignee:
UNIV VANDERBILT (US)
International Classes:
C07D519/00; A61K31/437; A61P25/36
Attorney, Agent or Firm:
CARROLL, William A. et al. (US)
Download PDF: