COMPLEMENT-INHIBITORY HYBRID PROTEIN MUTANT AND ANTIBODY FUSION PROTEIN THEREOF

Title:

COMPLEMENT-INHIBITORY HYBRID PROTEIN MUTANT AND ANTIBODY FUSION PROTEIN THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/099320

Kind Code:

A1

Abstract:

A hybrid protein containing a CFH functional unit and a DAF functional unit, and a mutant thereof, an encoding nucleic acid thereof, and a method and the use thereof for treating diseases or conditions related to a complement system; and a fusion protein constructed on the basis of the hybrid protein mutant and an antibody specifically binding to complement C5. Further provided are a polynucleotide for encoding said fusion protein, an expression vector and a host cell, a pharmaceutical composition thereof, and a method and the use thereof for treating C5-protein-related diseases.

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WO/2003/089475	ANTIBODIES, RECOMBINANT ANTIBODIES, RECOMBINANT ANTIBODY FRAGMENTS AND FUSIONS MEDIATED PLANT DISEASE RESISTANCE AGAINST FUNGI

Inventors:

MA HAILI (CN)
LIU HENG (CN)

Application Number:

PCT/CN2023/130258

Publication Date:

May 16, 2024

Filing Date:

November 07, 2023

Export Citation:

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Assignee:

LONGBIO PHARMA SUZHOU CO LTD (CN)

International Classes:

C07K19/00; A61K38/17; A61P7/04; A61P43/00; C12N5/10; C12N15/62; C12N15/85

Attorney, Agent or Firm:

ZHONGZI LAW OFFICE (CN)

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