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Title:
COMPLEX OF 3-HYDROXYBUTYRIC ACID AND SODIUM 3-HYDROXYBUTYRATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/067584
Kind Code:
A1
Abstract:
A complex, comprising 3-hydroxybutyric acid and sodium 3-hydroxybutyrate. The 3-hydroxybutyric acid and sodium 3-hydroxybutyrate are in a ratio of 1: 10 to 10: 1. The preparation method therefor comprises: (1) obtaining substance A by means of one of the following methods: mixing 3-hydroxybutyric acid and sodium 3-hydroxybutyrate; or adding 3-hydroxybutyric acid to an aqueous solution of alkaline Na compound, stirring the mixture, and carrying out distillation to remove the water until the product is nearly dry; or heating the alkyl 3-hydroxybutyrate and water in the presence of a catalyst for a reaction, carrying out cooling and filtering, adding an aqueous solution of alkaline Na compound to the filtrate, and carrying out distillation under reduced pressure to remove the water until the product is nearly dry; (2) adding one or more solvents selected from the following materials to the substance A obtained in step (1): water, THF, DMF, DMSO, DMAC, alcohols, halogenated hydrocarbons, ketones and esters, stirring and cooling the mixture to precipitate out a solid; and (3) filtering out the solid and drying same to obtain the complex. The use of the complex in the preparation of a ketogenic substance for raising or maintaining the blood ketone level in a subject.

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Inventors:
RONG LIANG (CN)
ZHU JINJIAN (CN)
CHEN YOUJIAN (CN)
JIANG LONG (CN)
ZHU XI (CN)
LIAO KYLIN (CN)
Application Number:
PCT/CN2023/121529
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
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Assignee:
NANJING NUTRABUILDING BIO TECH CO LTD (CN)
International Classes:
A23L33/10; A23L33/12; A61K31/19; A61P3/04
Foreign References:
CN109734575A2019-05-10
US20220023242A12022-01-27
CN113747890A2021-12-03
CN109369372A2019-02-22
CN109480284A2019-03-19
CN109700021A2019-05-03
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