Title:
A COMPLEX BETWEEN FOLIC ACID AND POLYSACCHARIDES, ITS PREPARATION METHOD AND A PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPLEX AS ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2001/079302
Kind Code:
A1
Abstract:
This invention relates to a complex between folic acid and polysaccharides and its preparation method, especially relates to a complex between folic acid and dextran, its preparation method and a pharmaceutical composition comprising said complex as active component, and also the use of such complex in anti-tumor. The general formula of the complex is as follows: (X)¿n?-Y, wherein X can be the same or different, and is selected from folic acid and its derivatives or other substances targeting cells through FR of the cell membrane, Y is polysaccharides and n $m(G)1.
Inventors:
LU WEIYUE (CN)
LIU MIN (CN)
PAN JUN (CN)
LIU MIN (CN)
PAN JUN (CN)
Application Number:
PCT/CN2001/000555
Publication Date:
October 25, 2001
Filing Date:
April 16, 2001
Export Citation:
Assignee:
UNIV FUDAN (CN)
LU WEIYUE (CN)
LIU MIN (CN)
PAN JUN (CN)
LU WEIYUE (CN)
LIU MIN (CN)
PAN JUN (CN)
International Classes:
A61K9/48; A61K31/715; A61K31/718; A61K9/19; A61K31/721; A61K31/727; A61K31/787; A61P35/00; A61P35/04; C08B30/18; C08B37/00; C08B37/02; C08B37/10; (IPC1-7): C08B37/00; A61K31/715; A61P35/04
Domestic Patent References:
| WO1992011037A2 | 1992-07-09 |
Foreign References:
| US5045535A | 1991-09-03 | |||
| CN1081688A | 1994-02-09 | |||
| GB1201014A | 1970-08-05 | |||
| US5547668A | 1996-08-20 | |||
| EP0383170A2 | 1990-08-22 | |||
| US4857505A | 1989-08-15 | |||
| JPS61207237A | 1986-09-13 | |||
| JPS59152327A | 1984-08-31 | |||
| US4046722A | 1977-09-06 |
Other References:
See also references of EP 1291362A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (2 Fuchengmenwai Sreet, Beijing 7, CN)
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