Title:
SILVER/POLYDIGUANIDE COMPLEX, PREPARATION METHOD THEREOF, AND ANTIBACTERIAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2011/046267
Kind Code:
A1
Abstract:
The present invention relates to a silver/polydiguanide complex and derivatives thereof including silver and polydiguanide having at least two biguanide moieties, wherein the silver is stabilized in an oxidation state of an integer of 0 to 4, a mole ratio between the silver and the polydiguanide is 1: 1-4, an average particle diameter of the complex is micrometer or nanometer, and zeta potential of the complex is greater than or equal to zero, a preparation method thereof, and an antibacterial composition for burns or wounds treatment including the same as an active ingredient. A silver/polydiguanide complex according to the present invention is different from conventional silver/polydiguanide complexes in carbon, hydrogen, and nitrogen contents as well as in structure of silver and polydiguanide, and solubility, is a material that exhibits a very good antibacterial activity due to a much lower minimal inhibitory concentration (MIC) value by 10 to 100 folds or more compared to silver sulfadiazine which is a conventional therapeutic agent for burns, and may be usefully used as an antibacterial composition for burns or wounds treatment.
Inventors:
SONG JOON MYONG (KR)
PAL SUKDEB (KR)
PAL SUKDEB (KR)
Application Number:
PCT/KR2010/000717
Publication Date:
April 21, 2011
Filing Date:
February 05, 2010
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
SONG JOON MYONG (KR)
PAL SUKDEB (KR)
SONG JOON MYONG (KR)
PAL SUKDEB (KR)
International Classes:
A61K33/38; A61K31/155; A61P17/00; A61P17/02; C07F1/10
Foreign References:
| US20090123513A1 | 2009-05-14 | |||
| US4654208A | 1987-03-31 | |||
| US20060062850A1 | 2006-03-23 |
Other References:
LAJOS BALOGH ET AL.: "Dendrimer silver complexes and nanocomposites as antimicrobial agents.", NANO LETTERS., vol. 1, no. ISS.1, 2001, pages 18 - 21
Attorney, Agent or Firm:
LEE, Won-Hee (642-16 Yoksam-dong Kangnam-ku, Seoul 135-080, KR)
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