Title:
COMPLEX FOR TREATING OPTIC NERVE DISEASE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/194109
Kind Code:
A1
Abstract:
Disclosed is a complex tFNA-miR22 for treating optic nerve disease, which complex is composed of tetrahedral DNA and miR-22 according to a molar ratio of 1: (1-4). The tFNA-miR22 can effectively inhibit apoptosis of retinal ganglion cells and promote the release of a brain-derived neurotrophic factor (BDNF), thereby achieving a good protection effect for the retinal ganglion cells. The tFNA-miR22 is used for preparing optic nerve protection drugs, the treatment of neurodegenerative optic nerve diseases including glaucoma is facilitated, and the tFNA-miR22 has very good application prospects.
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Inventors:
LIN YUNFENG (CN)
LI JIAJIE (CN)
CAI XIAOXIAO (CN)
LI JIAJIE (CN)
CAI XIAOXIAO (CN)
Application Number:
PCT/CN2022/080771
Publication Date:
September 22, 2022
Filing Date:
March 14, 2022
Export Citation:
Assignee:
CHENGDU GENREZE GENE TECH CO LTD (CN)
International Classes:
A61K31/711; A61K31/7105; A61P25/02; A61P27/06
Domestic Patent References:
| WO2013070821A1 | 2013-05-16 | |||
| WO2018226640A1 | 2018-12-13 |
Foreign References:
| CN112007044A | 2020-12-01 | |||
| CN109072189A | 2018-12-21 | |||
| CN109806275A | 2019-05-28 | |||
| CN112007044A | 2020-12-01 |
Other References:
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ZHENG QIJUN: "Nlrp1 Induces the Death of Retinal Ganglion Cells in Mice Sterile Optic Nerve Crush Injury", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE (ELECTRONIC JOURNALS), 15 March 2020 (2020-03-15), XP055966988
MOU LIN, LAI LI; YAN LI: "Correlation Between NLRP3 Inflammation Complex and the Degree of Optic Nerve Injury in Primary Glaucoma", GUOJI YANKE ZAZHI = INTERNATIONAL JOURNAL OF OPHTHALMOLOGY / INTERNATIONAL EYE SCIENCE, ZHONGHUA YIXUEHUI, XIAN FENHUI,, CN, vol. 19, no. 7, 31 July 2019 (2019-07-31), CN , pages 1123 - 1125, XP055966983, ISSN: 1672-5123, DOI: 10.3980/j.issn.1672-5123.2019.7.08
ZHANG, TAO ET AL.: "Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment", NATURE PROTOCOLS, vol. 15, no. 8, 15 July 2020 (2020-07-15), XP037207395, DOI: 10.1038/s41596-020-0355-z
ANDERS BJORKLUND AND ANGELA CENCI-NILSSON: "Event-Related Dynamics of Brain Oscillations", vol. 220, 1 January 2015, ELSEVIER, AMSTERDAM , NL , ISBN: 978-0-444-52183-5, ISSN: 0079-6123, article ROMANO GIOVANNI, PLATANIA CHIARA BIANCA MARIA, FORTE STEFANO, SALOMONE SALVATORE, DRAGO FILIPPO, BUCOLO CLAUDIO, BAGETTA GIACINTO: "Chapter 11: MicroRNA target prediction in glaucoma", pages: 217 - 240, XP009539960, DOI: 10.1016/bs.pbr.2015.04.013
ROMANO GLPLATANIA CBFORTE SSALOMONE SDRAGO FBUCOLO C: "MicroRNA target prediction in glaucoma", PROG BRAIN RES, vol. 220, 2015, pages 217 - 40, XP009539960, DOI: 10.1016/bs.pbr.2015.04.013
ZHENG QIJUN: "Nlrp1 Induces the Death of Retinal Ganglion Cells in Mice Sterile Optic Nerve Crush Injury", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE (ELECTRONIC JOURNALS), 15 March 2020 (2020-03-15), XP055966988
MOU LIN, LAI LI; YAN LI: "Correlation Between NLRP3 Inflammation Complex and the Degree of Optic Nerve Injury in Primary Glaucoma", GUOJI YANKE ZAZHI = INTERNATIONAL JOURNAL OF OPHTHALMOLOGY / INTERNATIONAL EYE SCIENCE, ZHONGHUA YIXUEHUI, XIAN FENHUI,, CN, vol. 19, no. 7, 31 July 2019 (2019-07-31), CN , pages 1123 - 1125, XP055966983, ISSN: 1672-5123, DOI: 10.3980/j.issn.1672-5123.2019.7.08
ZHANG, TAO ET AL.: "Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment", NATURE PROTOCOLS, vol. 15, no. 8, 15 July 2020 (2020-07-15), XP037207395, DOI: 10.1038/s41596-020-0355-z
ANDERS BJORKLUND AND ANGELA CENCI-NILSSON: "Event-Related Dynamics of Brain Oscillations", vol. 220, 1 January 2015, ELSEVIER, AMSTERDAM , NL , ISBN: 978-0-444-52183-5, ISSN: 0079-6123, article ROMANO GIOVANNI, PLATANIA CHIARA BIANCA MARIA, FORTE STEFANO, SALOMONE SALVATORE, DRAGO FILIPPO, BUCOLO CLAUDIO, BAGETTA GIACINTO: "Chapter 11: MicroRNA target prediction in glaucoma", pages: 217 - 240, XP009539960, DOI: 10.1016/bs.pbr.2015.04.013
ROMANO GLPLATANIA CBFORTE SSALOMONE SDRAGO FBUCOLO C: "MicroRNA target prediction in glaucoma", PROG BRAIN RES, vol. 220, 2015, pages 217 - 40, XP009539960, DOI: 10.1016/bs.pbr.2015.04.013
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LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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