Title:
POLYNUCLEOTIDE/SCHIZOPHYLLAN COMPOSITE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2016/098832
Kind Code:
A1
Abstract:
The present invention relates to a polynucleotide/schizophyllan composite that includes schizophyllan and a polynucleotide or a polynucleotide derivative that has a CpG sequence and is hydrogen bonded to the schizophyllan, the polynucleotide/schizophyllan composite being characterized by having a triple helical structure that comprises one molecular chain of the polynucleotide or the polynucleotide derivative and two molecular chains of the schizophyllan. The present invention also relates to a pharmaceutical composition that includes the polynucleotide/schizophyllan composite.
Inventors:
SAKURAI KAZUO (JP)
MOCHIZUKI SHINICHI (JP)
MOCHIZUKI SHINICHI (JP)
Application Number:
PCT/JP2015/085276
Publication Date:
June 23, 2016
Filing Date:
December 16, 2015
Export Citation:
Assignee:
PUBLIC UNIVERSITY CORP THE UNIVERSITY OF KITAKYUSHU (JP)
International Classes:
A61K47/48; A61K31/7088; A61K47/36; A61K48/00; A61P31/04; A61P35/00; A61P37/08
Domestic Patent References:
| WO2004100965A1 | 2004-11-25 |
Foreign References:
| JP2008100919A | 2008-05-01 |
Other References:
MIZU,M. ET AL.: "A polysaccharide carrier for immunostimulatory CpG DNA to enhance cytokine secretion", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 27, 2004, pages 8372 - 8373, XP055146435, ISSN: 0002-7863, DOI: doi:10.1021/ja031978+
SHIMADA,N. ET AL.: "Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CpG DNA Carrier", BIOCONJUGATE CHEMISTRY, vol. 17, no. 5, 2006, pages 1136 - 1140, XP055218957, ISSN: 1043-1802, DOI: doi:10.1021/bc060070g
SHIN'ICHI MOCHIZUKI ET AL.: "Selective delivery of oligonucletide using a beta-1,3-glucan receptor", DRUG DELIVERY SYSTEM, vol. 25, no. 6, 2010, pages 565 - 572, ISSN: 0913-5006
MOCHIZUKI,S. ET AL.: "Dectin-1 targeting delivery of TNF-alpha antisense ODNs complexed with beta-1,3- glucan protects mice from LPS-induced hepatitis", JOURNAL OF CONTROLLED RELEASE, vol. 151, no. 2, 2011, pages 155 - 161, XP055197019, ISSN: 0168-3659, DOI: doi:10.1016/j.jconrel.2011.01.026
MIZU,M. ET AL.: "Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan", BIOMATERIALS, vol. 25, no. 15, 2004, pages 3109 - 3116, XP004489064, ISSN: 0142-9612, DOI: doi:10.1016/j.biomaterials.2003.09.079
SHIMADA,N. ET AL.: "Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CpG DNA Carrier", BIOCONJUGATE CHEMISTRY, vol. 17, no. 5, 2006, pages 1136 - 1140, XP055218957, ISSN: 1043-1802, DOI: doi:10.1021/bc060070g
SHIN'ICHI MOCHIZUKI ET AL.: "Selective delivery of oligonucletide using a beta-1,3-glucan receptor", DRUG DELIVERY SYSTEM, vol. 25, no. 6, 2010, pages 565 - 572, ISSN: 0913-5006
MOCHIZUKI,S. ET AL.: "Dectin-1 targeting delivery of TNF-alpha antisense ODNs complexed with beta-1,3- glucan protects mice from LPS-induced hepatitis", JOURNAL OF CONTROLLED RELEASE, vol. 151, no. 2, 2011, pages 155 - 161, XP055197019, ISSN: 0168-3659, DOI: doi:10.1016/j.jconrel.2011.01.026
MIZU,M. ET AL.: "Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan", BIOMATERIALS, vol. 25, no. 15, 2004, pages 3109 - 3116, XP004489064, ISSN: 0142-9612, DOI: doi:10.1016/j.biomaterials.2003.09.079
Attorney, Agent or Firm:
NAKASHIMA KAZUAKI (JP)
Kazuaki Nakajima (JP)
Kazuaki Nakajima (JP)
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