Title:
COMPOSITION, BINDING INHIBITOR, MEDICAL DEVICE, AND METHOD FOR PREVENTING COVID-19
Document Type and Number:
WIPO Patent Application WO/2022/014693
Kind Code:
A1
Abstract:
Provided is a composition which contains a culture supernatant of dental pulp-derived stem cells, adipose-derived stem cells or umbilical cord-derived stem cells, or immortalized stem cells thereof. The composition contains angiotensin-converting enzyme 2 (ACE2) and is administered to a normal person or a normal animal to prevent a viral infection in which ACE2 acts as a receptor. The composition can be used as a prophylactic agent for a viral infection in which ACE2 acts as a receptor, e.g., COVID-19, when administered to a normal person or a normal animal.
Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2021/026716
Publication Date:
January 20, 2022
Filing Date:
July 16, 2021
Export Citation:
Assignee:
DEXON PHARMACEUTICALS INC (JP)
International Classes:
C12N5/00; A61K35/32; A61K35/35; A61K35/51; A61K38/43; A61P31/14; A61P43/00
Domestic Patent References:
| WO2018038180A1 | 2018-03-01 |
Foreign References:
| JP2017119646A | 2017-07-06 | |||
| JP2019524824A | 2019-09-05 | |||
| JP2018023343A | 2018-02-15 | |||
| JP6296622B2 | 2018-03-20 |
Other References:
GOLCHIN ALI; SEYEDJAFARI EHSAN; ARDESHIRYLAJIMI ABDOLREZA: "Mesenchymal Stem Cell Therapy for COVID-19: Present or Future", STEM CELL REVIEWS AND REPORTS, SPRINGER US, NEW YORK, vol. 16, no. 3, 13 April 2020 (2020-04-13), New York , pages 427 - 433, XP037149355, ISSN: 2629-3269, DOI: 10.1007/s12015-020-09973-w
SALDANHA-ARAUJO FELIPE, MELGAÇO GARCEZ EMÃNUELLA, SILVA-CARVALHO AMANDDA EVELIN, CARVALHO JULIANA LOTT: "Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 Treatment", FRONTIERS IN IMMUNOLOGY, vol. 11, 3 July 2020 (2020-07-03), XP055898287, DOI: 10.3389/fimmu.2020.01563
GENTILE PIETRO, STERODIMAS ARIS: "Adipose-derived stromal stem cells (ASCs) as a new regenerative immediate therapy combating coronavirus (COVID-19)-induced pneumonia", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 20, no. 7, 2 July 2020 (2020-07-02), pages 711 - 716, XP055898289, ISSN: 1471-2598, DOI: 10.1080/14712598.2020.1761322
J. BIOL. CHEM., vol. 280, no. 34, 26 August 2005 (2005-08-26), pages 30113 - 30119
STEM CELL REV REP, vol. 16, 13 April 2020 (2020-04-13), pages 427 - 433
PAIN PHYSICIAN, vol. 23, no. 2, 23 March 2020 (2020-03-23), pages E71 - E83
AGING AND DISEASE, no. 2, 11 April 2020 (2020-04-11), pages 216 - 228
FRONTIERS IN IMMUNOLOGY, vol. 11, no. 1563, 3 July 2020 (2020-07-03), pages 1 - 10
EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 20, no. 7, 29 April 2020 (2020-04-29), pages 711 - 716
SALDANHA-ARAUJO FELIPE, MELGAÇO GARCEZ EMÃNUELLA, SILVA-CARVALHO AMANDDA EVELIN, CARVALHO JULIANA LOTT: "Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 Treatment", FRONTIERS IN IMMUNOLOGY, vol. 11, 3 July 2020 (2020-07-03), XP055898287, DOI: 10.3389/fimmu.2020.01563
GENTILE PIETRO, STERODIMAS ARIS: "Adipose-derived stromal stem cells (ASCs) as a new regenerative immediate therapy combating coronavirus (COVID-19)-induced pneumonia", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 20, no. 7, 2 July 2020 (2020-07-02), pages 711 - 716, XP055898289, ISSN: 1471-2598, DOI: 10.1080/14712598.2020.1761322
J. BIOL. CHEM., vol. 280, no. 34, 26 August 2005 (2005-08-26), pages 30113 - 30119
STEM CELL REV REP, vol. 16, 13 April 2020 (2020-04-13), pages 427 - 433
PAIN PHYSICIAN, vol. 23, no. 2, 23 March 2020 (2020-03-23), pages E71 - E83
AGING AND DISEASE, no. 2, 11 April 2020 (2020-04-11), pages 216 - 228
FRONTIERS IN IMMUNOLOGY, vol. 11, no. 1563, 3 July 2020 (2020-07-03), pages 1 - 10
EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 20, no. 7, 29 April 2020 (2020-04-29), pages 711 - 716
Attorney, Agent or Firm:
SIKs & Co. (JP)
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