Title:
COMPOSITION FOR CARTILAGE REGENERATION PROMOTION
Document Type and Number:
WIPO Patent Application WO/2021/024801
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition for cartilage regeneration promotion and a cartilage regeneration promotion method that promote cartilage regeneration. The present invention pertains to a composition or the like that is for cartilage regeneration promotion and that contains a flavonoid represented by general formula (1) as an active ingredient. (In the formula, R1, R2, R3, R4, and R5 each independently represent a hydrogen atom or a hydroxy group. R6 represents a hydroxy group or an alkoxy group having 1 or 2 carbon atoms. One of R7 and R8 represents a hydrogen atom, and the other represents a hydroxy group or an alkoxy group having 1 or 2 carbon atoms. A dashed line represents an optional bond.)
Inventors:
OTSUKA YUTA (JP)
FUNAKI AYUTA (JP)
FUNAKI AYUTA (JP)
Application Number:
PCT/JP2020/028306
Publication Date:
February 11, 2021
Filing Date:
July 21, 2020
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A61P19/04; A61K31/352; A61K31/353; A61P43/00
Foreign References:
| JP2007508371A | 2007-04-05 | |||
| JP2016520603A | 2016-07-14 | |||
| JP2016539090A | 2016-12-15 | |||
| JP2004002284A | 2004-01-08 | |||
| JP2017014164A | 2017-01-19 |
Other References:
WEI BING, ZHANG YAN, TANG LIXIA, JI YIKUI, YAN CHENG, ZHANG XIAOKE: "Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis", DRUG DEV RES., vol. 80, no. 3, 2019, pages 360 - 367, XP055791946
YUE MENGFAN, ZENG NI, XIA YUFENG, WEI ZHIFENG, DAI YUE: "Morin Exerts Anti-Arthritic Effects by Attenuating Synovial Angiogenesis via Activation of Peroxisome Proliferator Activated Receptor-y", MOL. NUTR. FOOD RES., vol. 62, 2018, pages 1 - 21, XP055791948
ZHOU FENG, MEI JINGTIAN, YUAN KAI, HAN XIUGUO, QIAO HAN, TANG TINGTING: "Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis", J CELL MOL MED., vol. 23, no. 6, 2019, pages 4395 - 4407, XP055791951
XIAO SHIPENG, LIU WENGUANG, BI JIANQIANG, LIU SHENGHOU, ZHAO HENG, GONG NINGJI, XING DEGUO, GAO HONGWEI, GONG MINGZHI: "Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair", JOURNAL OF INFLAMMATION (WEB, vol. 15, no. 14, 2018, XP055791977
LIU YINGCHUN, YAN XIAONING: "Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through AKT/FOXO1 signaling", J CELL BIOCHEM., vol. 120, no. 9, 2019, pages 14628 - 14635, XP055791980, DOI: https://doi.org/10.1002/jcb.28724
JIANG, Q. ET AL.: "Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from . OH-treated damage: bioassay and antioxidant mechanism", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 17, no. 242, 2017, pages 1 - 11, XP021244852
See also references of EP 4008401A4
YUE MENGFAN, ZENG NI, XIA YUFENG, WEI ZHIFENG, DAI YUE: "Morin Exerts Anti-Arthritic Effects by Attenuating Synovial Angiogenesis via Activation of Peroxisome Proliferator Activated Receptor-y", MOL. NUTR. FOOD RES., vol. 62, 2018, pages 1 - 21, XP055791948
ZHOU FENG, MEI JINGTIAN, YUAN KAI, HAN XIUGUO, QIAO HAN, TANG TINGTING: "Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis", J CELL MOL MED., vol. 23, no. 6, 2019, pages 4395 - 4407, XP055791951
XIAO SHIPENG, LIU WENGUANG, BI JIANQIANG, LIU SHENGHOU, ZHAO HENG, GONG NINGJI, XING DEGUO, GAO HONGWEI, GONG MINGZHI: "Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair", JOURNAL OF INFLAMMATION (WEB, vol. 15, no. 14, 2018, XP055791977
LIU YINGCHUN, YAN XIAONING: "Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through AKT/FOXO1 signaling", J CELL BIOCHEM., vol. 120, no. 9, 2019, pages 14628 - 14635, XP055791980, DOI: https://doi.org/10.1002/jcb.28724
JIANG, Q. ET AL.: "Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from . OH-treated damage: bioassay and antioxidant mechanism", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 17, no. 242, 2017, pages 1 - 11, XP021244852
See also references of EP 4008401A4
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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