Title:
COMPOSITION COMPRISING FIBROBLAST-DERIVED EXTRACELLULAR VESICLE AS ACTIVE INGREDIENT FOR TREATING SKIN AND MUCOSAL WOUND
Document Type and Number:
WIPO Patent Application WO/2021/256751
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising fibroblast-derived extracellular vesicles as an active ingredient for treating skin and mucosal wounds. It is identified that the fibroblast-derived extracellular vesicles are effectively internalized into endothelial cells and fibroblasts to increase the migration of cells to wound sites and induce collagen deposition and maturation thereby effectively promoting would healing at the skin wound sites, and to upregulate the expression of genes involved in inhibiting scar formation in wound sites thereby effectively reducing scarring. Accordingly, the composition comprising fibroblast-derived extracellular vesicles as an active ingredient can be provided as a therapeutic agent for skin and mucosal wounds.
Inventors:
AHN BYEONG-CHEOL (KR)
CHUNG HO YUN (KR)
GANGADARAN PRAKASH (KR)
OH EUN JUNG (KR)
CHUNG HO YUN (KR)
GANGADARAN PRAKASH (KR)
OH EUN JUNG (KR)
Application Number:
PCT/KR2021/006992
Publication Date:
December 23, 2021
Filing Date:
June 04, 2021
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K35/33; A61B5/00; A61L26/00; A61P17/02
Foreign References:
| CN110975000A | 2020-04-10 | |||
| JP5641388B2 | 2014-12-17 | |||
| KR20200037918A | 2020-04-10 | |||
| KR20170106149A | 2017-09-20 | |||
| KR20130068530A | 2013-06-26 | |||
| KR20190088895A | 2019-07-29 |
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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