Title:
COMPOSITION COMPRISING FLAGELLIN AND IMMUNOGLOBULIN FC FUSION PROTEIN FOR TREATMENT OF LIVER DISEASE OR METABOLIC SYNDROME
Document Type and Number:
WIPO Patent Application WO/2023/204564
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising a flagellin and immunoglobulin Fc fusion protein for the treatment of liver disease or metabolic syndrome and, more specifically, concerns a composition comprising a fusion protein including flagellin and a variant of human IgG4 Fc for the treatment of liver disease or metabolic syndrome, wherein the variant of human IgG4 Fc possesses a mutation that prevents Fab arm exchange.
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Inventors:
CHO KYUNG A (KR)
Application Number:
PCT/KR2023/005213
Publication Date:
October 26, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
MEDISPAN CO LTD (KR)
UNIV NAT CHONNAM IND FOUND (KR)
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
A61K38/16; A23L33/195; A61K47/68; A61P1/16; A61P3/00
Foreign References:
| KR20200123751A | 2020-10-30 | |||
| KR20190095946A | 2019-08-16 | |||
| US20210061919A1 | 2021-03-04 |
Other References:
HANDLOGTEN MICHAEL W., PENG LI, CHRISTIAN ELIZABETH A., XU WEICHEN, LIN SHIHUA, VENKAT RAGHAVAN, DALL’ACQUA WILLIAM, AHUJA SANJEEV: "Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region", MABS, LANDES BIOSCIENCE, US, vol. 12, no. 1, 1 January 2020 (2020-01-01), US , pages 1779974, XP055869374, ISSN: 1942-0862, DOI: 10.1080/19420862.2020.1779974
XU CHANG-AI, FENG ANDREW Z., RAMINENI CHARAN K., WALLACE MATTHEW R., CULYBA ELIZABETH K., GUAY KEVIN P., MEHTA KINJAL, MABRY ROBER: "L 445 P mutation on heavy chain stabilizes IgG 4 under acidic conditions", MABS, LANDES BIOSCIENCE, US, vol. 11, no. 7, 3 October 2019 (2019-10-03), US , pages 1289 - 1299, XP093101946, ISSN: 1942-0862, DOI: 10.1080/19420862.2019.1631116
XU CHANG-AI, FENG ANDREW Z., RAMINENI CHARAN K., WALLACE MATTHEW R., CULYBA ELIZABETH K., GUAY KEVIN P., MEHTA KINJAL, MABRY ROBER: "L 445 P mutation on heavy chain stabilizes IgG 4 under acidic conditions", MABS, LANDES BIOSCIENCE, US, vol. 11, no. 7, 3 October 2019 (2019-10-03), US , pages 1289 - 1299, XP093101946, ISSN: 1942-0862, DOI: 10.1080/19420862.2019.1631116
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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