Title:
COMPOSITION COMPRISING ISOLATED OR ENRICHED PHOSPHOENOLPYRUVATE OR A SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/071319
Kind Code:
A1
Abstract:
The present disclosure provides a composition comprising a glycolytic intermediate metabolite or a salt thereof, preferably, phosphoenolpyruvate (PEP), glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), or 3-phosphoglycerate (3PG), or a salt thereof, more preferably, phosphoenolpyruvate (PEP) or a salt thereof. The composition can be a pharmaceutical composition for use in treating immune-related disease, such as autoimmune disease, and disease associated with an activated or increased T helper 17 cell.
More Like This:
Inventors:
ISHIKAWA HIROKI (JP)
HUANG TSUNG-YEN (JP)
HUANG TSUNG-YEN (JP)
Application Number:
PCT/JP2023/035468
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP)
International Classes:
A61K31/661; A61P37/00
Domestic Patent References:
| WO2020232357A1 | 2020-11-19 |
Foreign References:
| US8058069B2 | 2011-11-15 |
Other References:
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ANGIARI, S., RUNTSCH, M.C., SUTTON, C.E., PALSSON-MCDERMOTT, E.M., KELLY, B., RANA, N., KANE, H., PAPADOPOULOU, G., PEARCE, E.L., : "Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4(+) T Cell Pathogenicity and Suppresses Autoimmunity", CELL METAB, vol. 31, 2020, pages 391 - 405
BETTELLI, E.CARRIER, Y.GAO, W.KORN, T.STROM, T.B.OUKKA, M.WEINER, H.L.KUCHROO, V.K.: "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells", NATURE, vol. 441, 2006, pages 235 - 238, XP055049368, DOI: 10.1038/nature04753
BRUCKLACHER-WALDERT, V.FERREIRA, C.STEBEGG, M.FESNEAU, O.INNOCENTIN, S.MARIE, J.C.VELDHOEN, M.: "Cellular Stress in the Context of an Inflammatory Environment Supports TGF-beta-Independent T Helper-17 Differentiation", CELL REP, vol. 19, 2017, pages 2357 - 2370
BRUSTLE, A.HEINK, S.HUBER, M.ROSENPLANTER, C.STADELMANN, C.YU, P.ARPAIA, E.MAK, T.W.KAMRADT, T.LOHOFF, M.: "The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4", NAT IMMUNOL, vol. 8, 2007, pages 958 - 966, XP055044562, DOI: 10.1038/ni1500
CARR, T.M.WHEATON, J.D.HOUTZ, G.M.CIOFANI, M.: "JunB promotes Thl7 cell identity and restrains alternative CD4(+) T-cell programs during inflammation", NAT COMMUN, vol. 8, 2017, pages 301
CHAPMAN, N.M.BOOTHBY, M.R.CHI, H.: "Metabolic coordination of T cell quiescence and activation", NAT REV IMMUNOL, vol. 20, 2020, pages 55 - 70, XP036976385, DOI: 10.1038/s41577-019-0203-y
CIOFANI, M.MADAR, A.GALAN, C.SELLARS, M.MACE, K.PAULI, F.AGARWAL, A.HUANG, W.PARKHURST, C.N.MURATET, M. ET AL.: "A validated regulatory network for Thl7 cell specification", CELL, vol. 151, 2012, pages 289 - 303, XP055044458, DOI: 10.1016/j.cell.2012.09.016
CUA, D.J.SHERLOCK, J.CHEN, Y.MURPHY, C.A.JOYCE, B.SEYMOUR, B.LUCIAN, L.TO, W.KWAN, S.CHURAKOVA, T. ET AL.: "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain", NATURE, vol. 421, 2003, pages 744 - 748, XP002971969, DOI: 10.1038/nature01355
DAMASCENE, L.E.A.PRADO, D.S.VERAS, F.P.FONSECA, M.M.TOLLER-KAWAHISA, J.E.ROSA, M.H.PUBLIO, G.A.MARTINS, T.V.RAMALHO, F.S.WAISMAN, : "PKM2 promotes Thl7 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation", J EXP MED, 2020, pages 217
GELTINK, R.I.K.KYLE, R.L.PEARCE, E.L.: "Unraveling the Complex Interplay Between T Cell Metabolism and Function", ANNU REV IMMUNOL, vol. 36, 2018, pages 461 - 488
GHORESCHI, K.LAURENCE, A.YANG, X.P.TATO, C.M.MCGEACHY, M.J.KONKEL, J.E.RAMOS, H.L.WEI, L.DAVIDSON, T.S.BOULADOUX, N. ET AL.: "Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling", NATURE, vol. 467, 2010, pages 967 - 971
GLASMACHER, E.AGRAWAL, S.CHANG, A.B.MURPHY, T.L.ZENG, W.VANDER LUGT, B.KHAN, A.A.CIOFANI, M.SPOONER, C.J.RUTZ, S. ET AL.: "A genomic regulatory element that directs assembly and function of immune-specific AP-l-IRF complexes", SCIENCE, vol. 338, 2012, pages 975 - 980
HAMASAKI, N.KAWANO, Y.: "Phosphoenolpyruvate transport in the anion transport system of human erythrocyte membranes", TRENDS IN BIOCHEMICAL SCIENCES, vol. 12, 1987, pages 183 - 185, XP025902834, DOI: 10.1016/0968-0004(87)90089-2
HASAN, Z.KOIZUMI, S.I.SASAKI, D.YAMADA, H.ARAKAKI, N.FUJIHARA, Y.OKITSU, S.SHIRAHATA, H.ISHIKAWA, H.: "JunB is essential for IL-23-dependent pathogenicity of Thl7 cells", NAT COMMUN, vol. 8, 2017, pages 15628
HIROTA, K.TURNER, J.E.VILLA, M.DUARTE, J.H.DEMENGEOT, J.STEINMETZ, O.M.STOCKINGER, B.: "Plasticity of Thl7 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses", NAT IMMUNOL, vol. 14, 2013, pages 372 - 379
HO, P.C.BIHUNIAK, J.D.MACINTYRE, A.N.STARON, M.LIU, X.AMEZQUITA, R.TSUI, Y.C.CUI, G.MICEVIC, G.PERALES, J.C. ET AL.: "Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses", CELL, vol. 162, 2015, pages 1217 - 1228, XP055608265, DOI: 10.1016/j.cell.2015.08.012
HOCHREIN, S.M.WU, H.ECKSTEIN, M.ARRIGONI, L.HERMAN, J.S.SCHUMACHER, F.GERECKE, C.ROSENFELDT, M.GRUN, D.KLEUSER, B. ET AL.: "The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming", CELL METAB, vol. 34, 2022, pages 516 - 532
HSIEH, T.SASAKI, D.TAIRA, N.CHIEN, H.SARKAR, S.SETO, Y.MIYAGI, M.ISHIKAWA, H.: "JunB Is Critical for Survival of T Helper Cells", FRONT IMMUNOL, vol. 13, 2022, pages 901030
HUBER, M.BRUSTLE, A.REINHARD, K.GURALNIK, A.WALTER, G.MAHINY, A.VON LOW, E.LOHOFF, M.: "IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Thl7 phenotype", PROC NATL ACAD SCI USA, vol. 105, 2008, pages 20846 - 20851
IWATA, A.DURAI, V.TUSSIWAND, R.BRISENO, C.G.WU, X.GRAJALES-REYES, G.E.EGAWA, T.MURPHY, T.L.MURPHY, K.M.: "Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex", NAT IMMUNOL, vol. 18, 2017, pages 563 - 572
JEONG, G.-J.KANG, D.KIM, A.-K.HAN, K.-H.JEON, H.R.KIM, D.-I.: "Metabolites can regulate stem cell behavior through the STAT3/AKT pathway in a similar trend to that under hypoxic conditions", SCIENTIFIC REPORTS, vol. 9, 2019, pages 1 - 9
KONO, M.MAEDA, K.STOCTON-GAVANESCU, I.PAN, W.UMEDA, M.KATSUYAMA, E.BURBANO, C.ORITE, S.Y.K.VUKELIC, M.TSOKOS, M.G. ET AL.: "Pyruvate kinase M2 is requisite for Thl and Thl7 differentiation", JCI INSIGHT, 2019, pages 4
KORNBERG, M.D.BHARGAVA, P.KIM, P.M.PUTLURI, V.SNOWMAN, A.M.PUTLURI, N.CALABRESI, P.A.SNYDER, S.H.: "Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity", SCIENCE, vol. 360, 2018, pages 449 - 453
LAURENCE, A.TATO, C.M.DAVIDSON, T.S.KANNO, Y.CHEN, Z.YAO, Z.BLANK, R.B.MEYLAN, F.SIEGEL, R.HENNIGHAUSEN, L. ET AL.: "Interleukin-2 signaling via STATS constrains T helper 17 cell generation", IMMUNITY, vol. 26, 2007, pages 371 - 381
LEE, Y.AWASTHI, A.YOSEF, N.QUINTANA, F.J.XIAO, S.PETERS, A.WU, C.KLEINEWIETFELD, M.KUNDER, S.HAFLER, D.A. ET AL.: "Induction and molecular signature of pathogenic TH17 cells", NAT IMMUNOL, vol. 13, 2012, pages 991 - 999, XP055190404, DOI: 10.1038/ni.2416
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