Title:
COMPOSITION COMPRISING THE N-TERMINAL REGION OF LEISHMANIA HISTONE H2B, USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO2006097642
Kind Code:
A3
Abstract:
The invention concerns an immunogenic composition comprising: i) an antigenic polypeptide consisting of a fragment of the protein histone H2B of Leishmania, said fragment including the N-terminal region of said protein histone H2B, and ii) an adjuvant stimulating the immune response.
Inventors:
CHENIK MEHDI (TN)
LOUZIR HECHMI (TN)
DELLAGI KOUSSAY (TN)
LOUZIR HECHMI (TN)
DELLAGI KOUSSAY (TN)
Application Number:
PCT/FR2006/000597
Publication Date:
November 23, 2006
Filing Date:
March 17, 2006
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
PASTEUR INSTITUT TUNIS (TN)
CHENIK MEHDI (TN)
LOUZIR HECHMI (TN)
DELLAGI KOUSSAY (TN)
PASTEUR INSTITUT TUNIS (TN)
CHENIK MEHDI (TN)
LOUZIR HECHMI (TN)
DELLAGI KOUSSAY (TN)
International Classes:
A61K39/008; C07K14/44
Domestic Patent References:
| WO2005044301A2 | 2005-05-19 |
Other References:
IBORRA S ET AL: "Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosis", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 29-30, 28 September 2004 (2004-09-28), pages 3865 - 3876, XP004567462, ISSN: 0264-410X
SOTO M ET AL: "ANTIGENICITY OF THE LEISHMANIA INFANTUM HISTONES H2B AND H4 DURING CANINE VISCEROCUTANEOUS LEISHMANIASIS", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, OXFORD, GB, vol. 2, no. 115, February 1999 (1999-02-01), pages 342 - 349, XP001086535, ISSN: 0009-9104
MAALEJ IBTISSEM ABDMOULEH ET AL: "Comparative evaluation of ELISAs based on ten recombinant or purified Leishmania antigens for the serodiagnosis of Mediterranean visceral leishmaniasis.", AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 68, no. 3, March 2003 (2003-03-01), pages 312 - 320, XP002365318, ISSN: 0002-9637
DATABASE EMBL [online] 21 March 2001 (2001-03-21), "Leishmania major histone H2B (H2B) mRNA, complete cds.", XP002384653, retrieved from EBI accession no. EM_PRO:AF336276 Database accession no. AF336276
PROBST P ET AL: "Identification and characterization of T cell-stimulating antigens from Leishmania by CD4 T cell expression cloning.", THE JOURNAL OF IMMUNOLOGY, vol. 166, no. 1, 1 January 2001 (2001-01-01), pages 498 - 505, XP002365319, ISSN: 0022-1767
SOTO M ET AL: "ANTIGENICITY OF THE LEISHMANIA INFANTUM HISTONES H2B AND H4 DURING CANINE VISCEROCUTANEOUS LEISHMANIASIS", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, OXFORD, GB, vol. 2, no. 115, February 1999 (1999-02-01), pages 342 - 349, XP001086535, ISSN: 0009-9104
MAALEJ IBTISSEM ABDMOULEH ET AL: "Comparative evaluation of ELISAs based on ten recombinant or purified Leishmania antigens for the serodiagnosis of Mediterranean visceral leishmaniasis.", AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 68, no. 3, March 2003 (2003-03-01), pages 312 - 320, XP002365318, ISSN: 0002-9637
DATABASE EMBL [online] 21 March 2001 (2001-03-21), "Leishmania major histone H2B (H2B) mRNA, complete cds.", XP002384653, retrieved from EBI accession no. EM_PRO:AF336276 Database accession no. AF336276
PROBST P ET AL: "Identification and characterization of T cell-stimulating antigens from Leishmania by CD4 T cell expression cloning.", THE JOURNAL OF IMMUNOLOGY, vol. 166, no. 1, 1 January 2001 (2001-01-01), pages 498 - 505, XP002365319, ISSN: 0022-1767
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