Title:
COMPOSITION COMPRISING POLYGALATENOSIDE AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2023/128255
Kind Code:
A1
Abstract:
The present invention relates to a composition exhibiting an excellent prophylactic or therapeutic effect on cancer, the composition comprising polygalatenoside, an optical isomer thereof, or a pharmaceutically active ingredient thereof as an active ingredient. Having the effects of suppressing reactive oxygen species, inhibiting NOX2 protein activity, killing cancer cells, and repressing cancer cell growth, the polygalatenoside of the present invention exhibits a prophylactic, alleviative, or therapeutic effect on cancer and thus can be used as a pharmaceutical composition or a palliative food composition. In addition, the present invention can be used as an improved food composition or cosmetic composition that exhibits anti-aging or antioxidant effects due to the suppressive effect on reactive oxygen species.
Inventors:
KIM SUNG-JO (KR)
KIM HYUNGKUEN (KR)
KIM HYUNGKUEN (KR)
Application Number:
PCT/KR2022/017635
Publication Date:
July 06, 2023
Filing Date:
November 10, 2022
Export Citation:
Assignee:
UNIV HOSEO ACAD COOP FOUND (KR)
International Classes:
A61K31/7034; A23L33/125; A61K8/60; A61P35/00; A61Q19/08
Foreign References:
| JP2006022081A | 2006-01-26 | |||
| JPH09249688A | 1997-09-22 | |||
| US20080076724A1 | 2008-03-27 |
Other References:
BIAN YOUCHENG; ZENG HUI; TAO HONG; HUANG LULIN; DU ZHENYUN; WANG JIAO; DING KAN: "A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 162, 9 June 2020 (2020-06-09), NL , pages 107 - 115, XP086280569, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2020.06.054
KIM HYUNGKUEN; HWANG EUNMI; PARK BYUNG-CHUL; KIM SUNG-JO: "Novel potential NOX2 inhibitors, Dudleya brittonii water extract and polygalatenoside A inhibit intracellular ROS generation and growth of melanoma", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 150, 14 April 2022 (2022-04-14), FR , XP087074645, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2022.112967
KIM HYUNGKUEN; HWANG EUNMI; PARK BYUNG-CHUL; KIM SUNG-JO: "Novel potential NOX2 inhibitors, Dudleya brittonii water extract and polygalatenoside A inhibit intracellular ROS generation and growth of melanoma", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 150, 14 April 2022 (2022-04-14), FR , XP087074645, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2022.112967
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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