Title:
COMPOSITION COMPRISING PROTEIN KINASE C ACTIVATOR FOR PROMOTING STEM CELL ADHESION, AND METHOD FOR PROMOTING STEM CELL ADHESION
Document Type and Number:
WIPO Patent Application WO/2014/042292
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising a protein kinase C activator for promoting stem cell adhesion and to a method for promoting a stem cell adhesion. The protein kinase C activator according to the present invention promotes the phosphorylation of focal adhesion kinase (FAK) which is a signal transduction molecule associated with cell adhesion capacity in stem cells, and increases the expression of paxillin, talin, vinculin and Rac1 which is a GTPase, and thus enables stem cells to effectively adhere to a damaged area of the myocardium.
Inventors:
HWANG KI CHUL (KR)
CHANG WOO CHUL (KR)
CHANG WOO CHUL (KR)
Application Number:
PCT/KR2012/007308
Publication Date:
March 20, 2014
Filing Date:
September 12, 2012
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
CATHOLIC UNIV IND ACAD COOP (KR)
HWANG KI CHUL (KR)
CHANG WOO CHUL (KR)
CATHOLIC UNIV IND ACAD COOP (KR)
HWANG KI CHUL (KR)
CHANG WOO CHUL (KR)
International Classes:
A61K31/121; A61K38/46; A61K38/55; A61P9/00
Foreign References:
| KR20060108658A | 2006-10-18 | |||
| KR20090025989A | 2009-03-11 | |||
| KR20090045940A | 2009-05-08 |
Other References:
CHOI, EUN JU: "Enhancement of mesenchymal stem cell adhesion by PKC activation", MASTER'S THESIS, February 2011 (2011-02-01), YONSEI UNIVERSITY GRADUATE SCHOOL
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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