Title:
COMPOSITION COMPRISING SKIN-SPECIFIC T CELL INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF ATOPIC DERMATITIS
Document Type and Number:
WIPO Patent Application WO/2023/080704
Kind Code:
A1
Abstract:
The present invention relates to a composition for the prevention or treatment of inflammatory or autoimmune skin diseases. The present invention can be effectively used as a fundamental therapeutic composition that can efficiently ameliorate skin tissue damage caused by inflammation, while minimizing the effect on systemic immune activity, by specifically inhibiting the activity of skin-specific T cells. In addition, the composition of the present invention is efficiently delivered to the stratum corneum of the skin and thus can exert a lesion-specific and intensive immune control effect as a topical skin application agent. Furthermore, the composition exhibits little toxicity to normal skin tissue and thus is suitable for long-term administration for the treatment of atopic dermatitis, which is a chronic disease. The present invention also provides a screening method that can rapidly search, with high reliability, for promising therapeutic candidates capable of alleviating various autoimmune and inflammatory damage occurring in skin tissue on the basis of the newly investigated correlation between the skin-specific T cells and PIK3CD protein.
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Inventors:
PARK CHANG OOK (KR)
KIM YU RI (KR)
KIM SU MIN (KR)
KIM HYE LI (KR)
ZHANG KELUN (KR)
KIM HYUN SOO (KR)
KIM YU RI (KR)
KIM SU MIN (KR)
KIM HYE LI (KR)
ZHANG KELUN (KR)
KIM HYUN SOO (KR)
Application Number:
PCT/KR2022/017214
Publication Date:
May 11, 2023
Filing Date:
November 04, 2022
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/52; A61K8/49; A61K9/00; A61P17/00; A61P29/00; A61P37/00; A61Q17/00; G01N33/68
Domestic Patent References:
| WO2005120511A1 | 2005-12-22 |
Foreign References:
| KR20180008299A | 2018-01-24 | |||
| KR20170010369A | 2017-01-31 | |||
| US20050054614A1 | 2005-03-10 |
Other References:
MACHAN SALMA, PLAZA CARLOS, PÉREZ-GONZÁLEZ YOSMAR, RODRIGUEZ-PINILLA MARIA, REQUENA LUIS, CORDOBA RAUL: "Management of psoriasis-like rash associated with idelalisib monotherapy in a patient with refractory follicular lymphoma: a case report", JOURNAL OF MEDICAL CASE REPORTS, vol. 14, no. 1, 1 December 2020 (2020-12-01), pages 35, XP093062379, DOI: 10.1186/s13256-020-2344-9
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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