Title:
COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/019329
Kind Code:
A1
Abstract:
The present disclosure provides a composition that contains, for example, 2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-methyl-(methysulfamoylamino)pyridin-4-yl]methyl]banzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt, a dispersant (for example, methyl cellulose) and/or a basic compound (for example, meglumine). According to the present disclosure, provided is a composition containing a specific arylamide derivative that has an RAF/MEK complex stabilizing activity and/or MEK inhibitory activity and is useful for treating or preventing cell proliferative diseases, in particular, cancer. This composition has excellent characteristics concerning the dissolution properties and/or stability of the arylamide derivative therein.
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Inventors:
KANOH TAKEO (JP)
NAKAE SHINICHI (JP)
NAKAE SHINICHI (JP)
Application Number:
PCT/JP2021/027316
Publication Date:
January 27, 2022
Filing Date:
July 21, 2021
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/44; A61K9/20; A61K9/48; A61K31/18; A61K31/337; A61K31/341; A61K31/351; A61K31/437; A61K31/4427; A61K31/443; A61K31/4433; A61K31/444; A61K31/506; A61K47/02; A61K47/12; A61K47/18; A61K47/26; A61K47/32; A61K47/38; A61P35/00; A61P43/00
Domestic Patent References:
| WO2021149776A1 | 2021-07-29 | |||
| WO2006011466A1 | 2006-02-02 | |||
| WO2005028426A1 | 2005-03-31 | |||
| WO2006011466A1 | 2006-02-02 | |||
| WO2007091736A1 | 2007-08-16 |
Foreign References:
| JP2007511613A | 2007-05-10 | |||
| JP2013508320A | 2013-03-07 | |||
| CH2676651A |
Other References:
EDITED BY JAPAN PHARMACEUTICAL ADDITIVES ASSOCIATION: "Japanese Pharmaceutical Excipients Directory 2016", 18 February 2016, JAPAN PHARMACEUTICAL ADDITIVES ASSOCIATION , JP , ISBN: 978-4-8408-1329-7, article INTERNATIONAL PHARMACEUTICAL EXCIPIENTS COUNCIL JAPAN: "Passage; Japanese Pharmaceutical Excipients Directory 2016", pages: 555 - 556, 566-567, XP009543103
NATURE, vol. 15, 2018, pages 709 - 720
MOLECULES, vol. 22, 2017, pages 1551
N. ENGL. J. MED., vol. 367, 2012, pages 1694 - 1703
JAMA., vol. 317, no. 18, 2017, pages 1844 - 1853
ANN. ONCOL., vol. 26, no. 5, 2015, pages 894 - 901
CANCER RES., vol. 73, no. 13, 2013, pages 4050 - 4060
CANCER CELL, vol. 25, no. 5, 2014, pages 697 - 710
J. CLIN. ONCOL., vol. 35, no. 15, 2017
NAT. REV. CLIN. ONCOL., vol. 11, 2014, pages 385 - 400
THE JAPANESE PHARMACOPOEIA
CHEM. REV., vol. 95, no. 7, 1995, pages 2457
ACC. CHEM. RES., vol. 41, pages 1461
TETRAHEDRON, vol. 48, no. 44, 1992, pages 9577
ALDRICHIMICA ACTA., vol. 38, 2005, pages 71
CHEM. SOC. REV., vol. 40, 2011, pages 5048
NATURE, vol. 15, 2018, pages 709 - 720
MOLECULES, vol. 22, 2017, pages 1551
N. ENGL. J. MED., vol. 367, 2012, pages 1694 - 1703
JAMA., vol. 317, no. 18, 2017, pages 1844 - 1853
ANN. ONCOL., vol. 26, no. 5, 2015, pages 894 - 901
CANCER RES., vol. 73, no. 13, 2013, pages 4050 - 4060
CANCER CELL, vol. 25, no. 5, 2014, pages 697 - 710
J. CLIN. ONCOL., vol. 35, no. 15, 2017
NAT. REV. CLIN. ONCOL., vol. 11, 2014, pages 385 - 400
THE JAPANESE PHARMACOPOEIA
CHEM. REV., vol. 95, no. 7, 1995, pages 2457
ACC. CHEM. RES., vol. 41, pages 1461
TETRAHEDRON, vol. 48, no. 44, 1992, pages 9577
ALDRICHIMICA ACTA., vol. 38, 2005, pages 71
CHEM. SOC. REV., vol. 40, 2011, pages 5048
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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