COMPOSITION CONTAINING DECURSIN OR DECURSINOL ANGELATE FOR TREATING ANGIOGENESIS-RELATED DISEASES

Title:

COMPOSITION CONTAINING DECURSIN OR DECURSINOL ANGELATE FOR TREATING ANGIOGENESIS-RELATED DISEASES

Document Type and Number:

WIPO Patent Application WO/2010/008129

Kind Code:

A1

Abstract:

The present invention is a composition which contains a decursin or decursinol angelate as an active ingredient for preventing or treating diseases which are related to angiogenesis induced by a VEGF (Vascular Endothelial Growth Factor). The decursin and decursinol angelate in the present invention can prevent and treat diseases which are related to VEGF-induced angiogenesis by blocking ERK (Extracellular Signal-Regulated Kinase )- and JNK (c-Jun N-terminal Kinase)-MARK (Mitogen-Activated- Protein Kinase)-activated signal transduction and suppressing MMP-2 (Matrix Metalloproteinase-2) activation through inhibition of VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2) phosphorylation.

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Inventors:

LEE YOU MIE (KR)

Application Number:

PCT/KR2009/001800

Publication Date:

January 21, 2010

Filing Date:

April 08, 2009

Export Citation:

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Assignee:

KYUNGPOOK NAT UNIV IND ACAD (KR)
LEE YOU MIE (KR)

International Classes:

A61K31/37

Domestic Patent References:

WO2000023074A1	2000-04-27
WO2005123063A1	2005-12-29
WO2001052841A1	2001-07-26

Foreign References:

KR20080004332A	2008-01-09
KR20050017630A	2005-02-22
KR20060078343A	2006-07-05
US20070264370A1	2007-11-15
KR20060066174A	2006-06-16
KR20060066175A	2006-06-16
KR20060066176A	2006-06-16
KR20060066177A	2006-06-16

Other References:

RANA P SINGH ET AL.: "Mechanisms of action of novel agents for prostate cancer chemoprevention.", ENDOCRINE-RELATED CANCER., vol. 13, no. 3, 2006, pages 751 - 778
CHENG JIANG ET AL.: "Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells.", BREAST CANCER RESEARCH., vol. 9, no. 6, 2007, pages R77

Attorney, Agent or Firm:

KIM, SOON-WOONG (KR)
김순웅 (KR)

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