Title:
COMPOSITION CONTAINING HEMATOPOIESIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/1994/013702
Kind Code:
A1
Abstract:
A composition containing a hematopoiesis inhibitor that inhibits CFU-E colony formation and comprising a substance present in the filtrate obtained by concentrating a dialyzate, obtained by dialyzing blood through a dialysis membrane having an albumin sieving coefficient of 0.01 or above, with a membrane having a fractionating molecular weight of 5,000 or less and then filtering the concentrate with a gel having a maximum fractionating molecular weight ranging from 0.2 to 1.5 million. The invention also relates to a method of treating blood characterized by removing an AI component so as to satisfy the following relationship: AI/AA 1/50 wherein AI represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and AA represents the height of the maximum absorbance value in the gel filtration pattern. The invention further relates to a dialysis membrane characterised in that the following relationship holds: AI/AA 1/50 wherein AI, represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and AA represents the height of the maximum absorbance value in the gel filtration pattern. In addition, the invention relates to a pharmaceutical composition and an erythrocytosis remedy each containing the hematopoiesis inhibitor.
Inventors:
YAMADA TOMOKO (JP)
KATAOKA HIROSHI (JP)
KATAOKA HIROSHI (JP)
Application Number:
PCT/JP1993/001766
Publication Date:
June 23, 1994
Filing Date:
December 03, 1993
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
YAMADA TOMOKO (JP)
KATAOKA HIROSHI (JP)
YAMADA TOMOKO (JP)
KATAOKA HIROSHI (JP)
International Classes:
C07K14/47; C07K14/52; A61K38/00; (IPC1-7): C07K15/06; C07K3/26; C07K3/18; A61M1/16; A61M1/34; A61K37/02; A61K35/16
Foreign References:
| JPH01287039A | 1989-11-17 | |||
| JPS5218807A | 1977-02-12 | |||
| JPS63109871A | 1988-05-14 |
Other References:
See also references of EP 0648782A4
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