Title:
COMPOSITION, CULTURE MEDIUM, METHOD AND KIT FOR AMPLIFYING HEMATOPOIETIC STEM CELL
Document Type and Number:
WIPO Patent Application WO/2021/088294
Kind Code:
A1
Abstract:
Provided are a composition for amplifying a hematopoietic stem cell and a culture medium, kit, and pharmaceutical composition comprising the composition, the use thereof and a method for amplifying a hematopoietic stem cell. The composition is composed of JNK-IN-8, nicotinamide adenine dinucleotide, rapamycin and Y27632.
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Inventors:
CHEN LIGONG (CN)
SUN ZHONGJIE (CN)
XIAO XIONG (CN)
LIU YINGQUAN (CN)
LIU DEFANG (CN)
QI HAILONG (CN)
GUO XIAO (CN)
WANG XIAOFANG (CN)
SUN ZHONGJIE (CN)
XIAO XIONG (CN)
LIU YINGQUAN (CN)
LIU DEFANG (CN)
QI HAILONG (CN)
GUO XIAO (CN)
WANG XIAOFANG (CN)
Application Number:
PCT/CN2020/080030
Publication Date:
May 14, 2021
Filing Date:
March 18, 2020
Export Citation:
Assignee:
NEWISH TECH BEIJING CO LTD (CN)
International Classes:
C12N5/0789; A61K31/439; A61K31/4409; A61K31/506; A61K31/7084; A61P35/00; A61P35/02; A61P37/00; C12Q1/02
Foreign References:
| CN110564687A | 2019-12-13 | |||
| CN108235708A | 2018-06-29 | |||
| CN109370988A | 2019-02-22 | |||
| CN103814126A | 2014-05-21 | |||
| CN102030821A | 2011-04-27 | |||
| CN108473949A | 2018-08-31 |
Other References:
XU GUOSHUN, MENG AI-MIN: "Research progress of regulative effects of mTOR signaling pathways on hematopoietic stem cells", ZHONGGUO YAOLIXUE TONGBAO - CHINESE PHARMACOLOGICAL BULLETIN, LINCHUANG YAOLI YANJIUSUO, HEFEI, CN, vol. 29, no. 9, 1 September 2013 (2013-09-01), CN, pages 1185 - 1188, XP055810459, ISSN: 1001-1978
XIE YINLIANG: "Regulation of Erythroid Differentiation from Human Pluripotent Stem Cells by TGF-β Signaling", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES, 1 May 2012 (2012-05-01), XP055810461
GAUTHAMAN KALAMEGAM, FONG CHUI-YEE, SUBRAMANIAN ARJUNAN, BISWAS ARIJIT, BONGSO ARIFF: "ROCK Inhibitor Y-27632 Increases Thaw-Survival Rates and Preserves Stemness and Differentiation Potential of Human Wharton’s Jelly Stem Cells After Cryopreservation", STEM CELL REVIEWS AND REPORTS, HUMANA PRESS INC., US, vol. 6, no. 4, 1 December 2010 (2010-12-01), US, pages 665 - 676, XP055810462, ISSN: 1550-8943, DOI: 10.1007/s12015-010-9184-8
XIE YINLIANG: "Regulation of Erythroid Differentiation from Human Pluripotent Stem Cells by TGF-β Signaling", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES, 1 May 2012 (2012-05-01), XP055810461
GAUTHAMAN KALAMEGAM, FONG CHUI-YEE, SUBRAMANIAN ARJUNAN, BISWAS ARIJIT, BONGSO ARIFF: "ROCK Inhibitor Y-27632 Increases Thaw-Survival Rates and Preserves Stemness and Differentiation Potential of Human Wharton’s Jelly Stem Cells After Cryopreservation", STEM CELL REVIEWS AND REPORTS, HUMANA PRESS INC., US, vol. 6, no. 4, 1 December 2010 (2010-12-01), US, pages 665 - 676, XP055810462, ISSN: 1550-8943, DOI: 10.1007/s12015-010-9184-8
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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