Title:
COMPOSITION FOR DIAGNOSING GLAUCOMA COMPRISING PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/010162
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or diagnosing glaucoma, comprising a protein as an active ingredient. The present invention put efforts into research for the development of more effective and novel diagnosis for normal-tension glaucoma that has a high incidence rate. As a result, 12 biomarkers for diagnosing normal-tension glaucoma, which are differentially expressed in the aqueous humor, have been identified. By confirming that the expression of AMBP, IGFBP2, C7, B2M, CPB2, SERPIND1, and F12 proteins is up-regulated in the aqueous humor while the expression of DCD, ENO1, DSG1, and KPRP is down-regulated, the present invention has been completed. The present invention can be very useful in early diagnosis of normal-tension glaucoma (NTG).
Inventors:
JI YONG WOO (KR)
LEE SI HYUNG (KR)
LEE SI HYUNG (KR)
Application Number:
PCT/KR2023/001015
Publication Date:
January 11, 2024
Filing Date:
January 20, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
UNIV SOONCHUNHYANG IND ACAD COOP FOUND (KR)
UNIV SOONCHUNHYANG IND ACAD COOP FOUND (KR)
International Classes:
G01N33/68; A61P27/02; C12Q1/6883
Foreign References:
| KR20200112728A | 2020-10-05 | |||
| US20200341010A1 | 2020-10-29 |
Other References:
HUBENS W.H.G., MOHREN R.J.C., LIESENBORGHS I., EIJSSEN L.M.T., RAMDAS W.D., WEBERS C.A.B., GORGELS T.G.M.F.: "The aqueous humor proteome of primary open angle glaucoma: An extensive review", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD., LONDON., vol. 197, 1 August 2020 (2020-08-01), LONDON. , pages 108077, XP093126444, ISSN: 0014-4835, DOI: 10.1016/j.exer.2020.108077
KAESLIN MARTHA ANDREA, KILLER HANSPETER EZRIEL, FUHRER CYRIL ADRIAN, ZELENY NAUKE, HUBER ANDREAS ROBERT, NEUTZNER ALBERT: "Changes to the Aqueous Humor Proteome during Glaucoma", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 11, no. 10, 27 October 2016 (2016-10-27), US , pages e0165314, XP093126448, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0165314
LEE SI HYUNG, JUNG JAE HUN, PARK TAE KWANN, MOON CHAE-EUN, HAN KYUSUN, LEE JINHYOUNG, LEE HYUNG KEUN, JI YONG WOO, KIM CHAN YUN: "Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 12, no. 1, US , XP093126449, ISSN: 2045-2322, DOI: 10.1038/s41598-022-05273-0
KAESLIN MARTHA ANDREA, KILLER HANSPETER EZRIEL, FUHRER CYRIL ADRIAN, ZELENY NAUKE, HUBER ANDREAS ROBERT, NEUTZNER ALBERT: "Changes to the Aqueous Humor Proteome during Glaucoma", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 11, no. 10, 27 October 2016 (2016-10-27), US , pages e0165314, XP093126448, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0165314
LEE SI HYUNG, JUNG JAE HUN, PARK TAE KWANN, MOON CHAE-EUN, HAN KYUSUN, LEE JINHYOUNG, LEE HYUNG KEUN, JI YONG WOO, KIM CHAN YUN: "Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 12, no. 1, US , XP093126449, ISSN: 2045-2322, DOI: 10.1038/s41598-022-05273-0
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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