Title:
COMPOSITION FOR ENHANCING ANTICANCER EFFECT OF MEK INHIBITOR COMPRISING ARIPIPRAZOLE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/219411
Kind Code:
A1
Abstract:
The present invention relates to a composition for enhancing the anticancer effect of an MEK inhibitor, the composition comprising aripiprazole as an active ingredient, and more specifically, to a composition for enhancing the anticancer effect of an MEK inhibitor, the composition being capable of treating cancer by acting as an anticancer effect enhancer of the MEK inhibitor when used in combination therapy with aripiprazole. An effective amount of aripiprazole according to the present invention is highly effective in improving the anticancer effect of the MEK inhibitor, such as by inducing cancer cell death, when administered in combination with the MEK inhibitor, and thus the present invention can be effectively used as an agent for improving the anticancer effect of the MEK inhibitor.
Inventors:
LIM YOUNG BIN (KR)
LEE HAE JUNE (KR)
KIM KWANG SEOK (KR)
LEE SOO HO (KR)
LEE HAE JUNE (KR)
KIM KWANG SEOK (KR)
LEE SOO HO (KR)
Application Number:
PCT/KR2023/006334
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
A61K31/496; A23L33/10; A61K31/519; A61K45/06; A61P35/00; A61P35/04
Foreign References:
| KR20220036878A | 2022-03-23 | |||
| KR20200111386A | 2020-09-29 | |||
| KR20170026115A | 2017-03-08 |
Other References:
KIM JI YEONG, TAE IN HWAN, LEE BYUNG-MU, KIM HYUNG SIK, YOON SUNGPIL: "Low Doses of the Anti-psychotic Drug Aripiprazole Have Strong P-gp-inhibitory Activity and Sensitize Anti-mitotic Drug-resistant Cancer Cells", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 38, no. 9, 1 September 2018 (2018-09-01), GR , pages 5101 - 5108, XP093106855, ISSN: 0250-7005, DOI: 10.21873/anticanres.12830
SHUHEI SUZUKI, MASASHI OKADA, KENTA KURAMOTO, HIROYUKI TAKEDA, HIROTSUGU SAKAKI, HIKARU WATARAI, TOMOMI SANOMACHI, SHIZUKA SEINO, : "Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 36, no. 10, 12 October 2016 (2016-10-12), GR , pages 5153 - 5162, XP055405053, ISSN: 0250-7005, DOI: 10.21873/anticanres.11085
BADRAN ADNAN, TUL-WAHAB ATIA, ZAFAR HUMAIRA, MOHAMMAD NAYAB, IMAD REHAN, ASHFAQ KHAN MARIAM, BAYDOUN ELIAS, CHOUDHARY M. IQBAL: "Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro", PLOS ONE, vol. 15, no. 8, 23 August 2020 (2020-08-23), pages e0235676, XP093106858, DOI: 10.1371/journal.pone.0235676
KIM MI SEON, BYONG CHUL YOO, WOO SEOK YANG, SANG YUN HAN, DEOK JEONG, JUN MIN SONG, KYUNG HEE KIM, ADITHAN ARAVINTHAN, JI HYE KIM: "Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action", ONCOTARGET., vol. 9, no. 5, 1 January 2018 (2018-01-01), pages 5979 - 5992, XP093106860, DOI: 10.18632/oncotarget.23192
SHUHEI SUZUKI, MASASHI OKADA, KENTA KURAMOTO, HIROYUKI TAKEDA, HIROTSUGU SAKAKI, HIKARU WATARAI, TOMOMI SANOMACHI, SHIZUKA SEINO, : "Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 36, no. 10, 12 October 2016 (2016-10-12), GR , pages 5153 - 5162, XP055405053, ISSN: 0250-7005, DOI: 10.21873/anticanres.11085
BADRAN ADNAN, TUL-WAHAB ATIA, ZAFAR HUMAIRA, MOHAMMAD NAYAB, IMAD REHAN, ASHFAQ KHAN MARIAM, BAYDOUN ELIAS, CHOUDHARY M. IQBAL: "Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro", PLOS ONE, vol. 15, no. 8, 23 August 2020 (2020-08-23), pages e0235676, XP093106858, DOI: 10.1371/journal.pone.0235676
KIM MI SEON, BYONG CHUL YOO, WOO SEOK YANG, SANG YUN HAN, DEOK JEONG, JUN MIN SONG, KYUNG HEE KIM, ADITHAN ARAVINTHAN, JI HYE KIM: "Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action", ONCOTARGET., vol. 9, no. 5, 1 January 2018 (2018-01-01), pages 5979 - 5992, XP093106860, DOI: 10.18632/oncotarget.23192
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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