Title:
COMPOSITION FOR ENHANCING EFFECT OF ANTIBODY DRUG
Document Type and Number:
WIPO Patent Application WO/2021/049587
Kind Code:
A1
Abstract:
Provided is a composition capable of enhancing the effect of an antibody drug such as an immune checkpoint inhibitor. In the composition for enhancing the effect of an antibody drug, β-glucan is used as an active ingredient. This composition is suitably usable for an antibody drug that has a function effect of suppressing cancer proliferation via immune check point inhibition, for example, an antibody drug comprising a monoclonal antibody against PD-L1.
Inventors:
RII KO (JP)
FUJINO MASAYUKI (JP)
MORIYA YUKIKO (JP)
FUJINO MASAYUKI (JP)
MORIYA YUKIKO (JP)
Application Number:
PCT/JP2020/034361
Publication Date:
March 18, 2021
Filing Date:
September 10, 2020
Export Citation:
Assignee:
AUREO CO LTD (JP)
NAT CT CHILD HEALTH & DEV (JP)
NAT CT CHILD HEALTH & DEV (JP)
International Classes:
A61K31/716; A23L33/10; A61K36/06; A61K39/395; A61P35/00; A61P43/00
Foreign References:
| JP2017524737A | 2017-08-31 | |||
| JP4000078B2 | 2007-10-31 | |||
| JP4054697B2 | 2008-02-27 | |||
| JP4369258B2 | 2009-11-18 | |||
| JPS5242855B2 | 1977-10-27 | |||
| JPS5331482B2 | 1978-09-02 | |||
| JPS5715659B2 | 1982-03-31 | |||
| JP5554221B2 | 2014-07-23 | |||
| JP5559173B2 | 2014-07-23 | |||
| JP5560472B2 | 2014-07-30 | |||
| JPS5937029B2 | 1984-09-07 | |||
| JP6293187B2 | 2018-03-14 | |||
| JP6380968B2 | 2018-08-29 |
Other References:
CLARK CURTIS A., GUPTA HARSHITA B., SAREDDY GANGADHARA, PANDESWARA SRILAKSHMI, LAO SHUNHUA, YUAN BIN, DRERUP JUSTIN M., PADRON ALV: "Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis, and autophagy in ovarian cancer and melanoma", CANCER RES., vol. 76, no. 23, 1 December 2016 (2016-12-01), pages 6965, XP055806131
KIMURA, YOSHIYUKI ET AL.: "P-1197: Antitumor and antimetastatic effects of beta-glucan in colon 26-implanted mice", CANCER SCIENCE, vol. 95, no. Suppl., 2004, pages 456, XP009532971
YAMASAKI, KAORI ET AL.: "3A07p24 Antitumor effect by oral administration of extracellular beta-glucan of black yeast", ANNUAL MEETING OF THE JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2004 (JSBBA 2004), vol. 2004, 5 March 2004 (2004-03-05), pages 165, XP009532931
ISHIDA, Y.AGATA, Y.SHIBAHARA, K.HONJO, T.: "Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death", EMBO J, vol. 11, 1992, pages 3887 - 3895, XP002070368
FREEMAN, G. J., LONG, A. J., IWAI, Y., BORQUE, K., CHERNOVA, T., NISHIMURA, H., FITSZ, L. J., MALENKOVICH, N., OKAZAKI, T., BYRNE,: "Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation", J. EXP., vol. 192, 2000, pages 1027 - 1034, XP002942545, DOI: 10.1084/jem.192.7.1027
SPENCER C. WEICOLM R. DUFFYJAMES P. ALLISON: "Fundamental Mechanisms of Immune Checkpoint Blockade Therapy", CANCER RESEARCH, 16 August 2018 (2018-08-16)
KIMURA, YOSHIYUKI ET AL.: "P-1197: Antitumor and antimetastatic effects of beta-glucan in colon 26-implanted mice", CANCER SCIENCE, vol. 95, no. Suppl., 2004, pages 456, XP009532971
YAMASAKI, KAORI ET AL.: "3A07p24 Antitumor effect by oral administration of extracellular beta-glucan of black yeast", ANNUAL MEETING OF THE JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2004 (JSBBA 2004), vol. 2004, 5 March 2004 (2004-03-05), pages 165, XP009532931
ISHIDA, Y.AGATA, Y.SHIBAHARA, K.HONJO, T.: "Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death", EMBO J, vol. 11, 1992, pages 3887 - 3895, XP002070368
FREEMAN, G. J., LONG, A. J., IWAI, Y., BORQUE, K., CHERNOVA, T., NISHIMURA, H., FITSZ, L. J., MALENKOVICH, N., OKAZAKI, T., BYRNE,: "Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation", J. EXP., vol. 192, 2000, pages 1027 - 1034, XP002942545, DOI: 10.1084/jem.192.7.1027
SPENCER C. WEICOLM R. DUFFYJAMES P. ALLISON: "Fundamental Mechanisms of Immune Checkpoint Blockade Therapy", CANCER RESEARCH, 16 August 2018 (2018-08-16)
Attorney, Agent or Firm:
SATO & ASSOCIATES (JP)
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