Title:
COMPOSITION HAVING ANTI-INFLAMMATORY AND ANTIVIRAL EFFECT, COMPRISING PLACENTAL EXTRACELLULAR VESICLES
Document Type and Number:
WIPO Patent Application WO/2021/225214
Kind Code:
A1
Abstract:
The present invention relates to the types and effects of placental extracellular vesicles (EVs) derived from placenta, umbilical cord, and umbilical cord blood, placental mesenchymal stem cells (pMSCs) derived from placenta, umbilical cord, and umbilical cord blood, EVs derived therefrom, and various biomolecules as well as miRNA and cargo included in the EVs. The present invention exhibits a direct antiviral effect as the miRNA included in the EV efficiently disintegrates the RNA genome of coronavirus, and also exhibits indirect prophylactic and therapeutic effects on various viral infections by virtue of an anti-inflammatory effect from various biomolecules inherent to the EV.
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Inventors:
MOON JI SOOK (KR)
Application Number:
PCT/KR2020/008277
Publication Date:
November 11, 2021
Filing Date:
June 25, 2020
Export Citation:
Assignee:
TS CELL BIO CO LTD (KR)
International Classes:
A61K35/28; A23L33/10; A61K31/7105; A61P29/00; A61P31/14
Foreign References:
| KR20120006386A | 2012-01-18 | |||
| JP2017536127A | 2017-12-07 | |||
| US20170114343A1 | 2017-04-27 | |||
| KR101555981B1 | 2015-09-30 |
Other References:
KHOURY MAROUN, CUENCA JIMENA, CRUZ FERNANDA F., FIGUEROA FERNANDO E., ROCCO PATRICIA R.M., WEISS DANIEL J.: "Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19", EUROPEAN RESPIRATORY JOURNAL, vol. 55, no. 6, 1 June 2020 (2020-06-01), GB , pages 2000858, XP055864603, ISSN: 0903-1936, DOI: 10.1183/13993003.00858-2020
KAUR SIPPY, ABU-SHAHBA AHMED G., PAANANEN RIKU O., HONGISTO HEIDI, HIIDENMAA HANNA, SKOTTMAN HELI, SEPPÄNEN-KAIJANSINKKO RIITTA, M: "Small non-coding RNA landscape of extracellular vesicles from human stem cells", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 15503, XP055864604, DOI: 10.1038/s41598-018-33899-6
WANG DE-JING, WANG CHEN-MEIYI, WANG YI-TING, QIAO HAI, FANG LIAO-QIONG, WANG ZHI-BIAO: "Lactation-Related MicroRNA Expression in Microvesicles of Human Umbilical Cord Blood", MEDICAL SCIENCE MONITOR, vol. 22, 1 January 2016 (2016-01-01), pages 4542 - 4554, XP055864609, DOI: 10.12659/MSM.901695
See also references of EP 4197548A4
KAUR SIPPY, ABU-SHAHBA AHMED G., PAANANEN RIKU O., HONGISTO HEIDI, HIIDENMAA HANNA, SKOTTMAN HELI, SEPPÄNEN-KAIJANSINKKO RIITTA, M: "Small non-coding RNA landscape of extracellular vesicles from human stem cells", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 15503, XP055864604, DOI: 10.1038/s41598-018-33899-6
WANG DE-JING, WANG CHEN-MEIYI, WANG YI-TING, QIAO HAI, FANG LIAO-QIONG, WANG ZHI-BIAO: "Lactation-Related MicroRNA Expression in Microvesicles of Human Umbilical Cord Blood", MEDICAL SCIENCE MONITOR, vol. 22, 1 January 2016 (2016-01-01), pages 4542 - 4554, XP055864609, DOI: 10.12659/MSM.901695
See also references of EP 4197548A4
Attorney, Agent or Firm:
SEO, Pyeong Gang (KR)
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